Goodman Jean R, Peck Jennifer D, Landmann Alessandra, Williams Marvin, Elimian Andrew
a Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology , Loyola University Medical Center , Maywood , IL , USA.
b University of Oklahoma Health Sciences Center , Oklahoma City , OK , USA.
J Matern Fetal Neonatal Med. 2019 Jul;32(14):2346-2353. doi: 10.1080/14767058.2018.1433657. Epub 2018 Feb 7.
The objective of this study is to evaluate poor maternal nutrition, environmental exposures and vasoactive stimulants as potential risk factors for gastroschisis.
A case-control study was conducted among singleton pregnancies diagnosed in a tertiary teaching hospital in a 22-month period. Cases of gastroschisis were matched to controls at the time of diagnosis by race and maternal age. Demographics, periconceptual exposures, nutritional biomarkers, and illicit drug hair analysis were evaluated. Analyses were performed using conditional logistic regression.
Thirty gastroschisis cases and 76 controls were studied with no associations observed for illicit drug use or serum levels of ferritin, iron, B6, B12, folate, or zinc. Neither prescription medication nor over the counter mediation use differed between cases and controls. Following adjustment for insurance, education, low BMI, and nulliparity, mothers of gastroschisis cases had an increased odds of alcohol use 1 month prior and/or during early pregnancy compared with controls, with adjusted odds ratio (OR) 3.19 (95% CI 1.01-11.61).
Our findings suggest that further investigation of vasoactive stimulants such as alcohol is warranted in the search to identify risk factors for gastroschisis.
本研究的目的是评估孕产妇营养状况不佳、环境暴露和血管活性刺激物作为腹裂潜在危险因素的情况。
在一家三级教学医院对22个月内诊断出的单胎妊娠进行病例对照研究。腹裂病例在诊断时按种族和孕产妇年龄与对照组进行匹配。评估了人口统计学、受孕前暴露情况、营养生物标志物和非法药物毛发分析。使用条件逻辑回归进行分析。
研究了30例腹裂病例和76例对照，未观察到非法药物使用或铁蛋白、铁、B6、B12、叶酸或锌的血清水平之间存在关联。病例组和对照组在处方药或非处方药使用方面均无差异。在对保险、教育程度、低体重指数和未生育情况进行调整后，与对照组相比，腹裂病例的母亲在妊娠前1个月和/或妊娠早期饮酒的几率增加，调整后的优势比（OR）为3.19（95%可信区间1.01 - 11.61）。
我们的研究结果表明，在寻找腹裂危险因素时，有必要对酒精等血管活性刺激物进行进一步调查。
