Scanning electron microscopy of antigen induced arthritic joints. I. Inflammatory cell interactions at synovial-meniscal surfaces during the Arthus response.

Scanning electron microscopy has been used to study experimental antigen induced arthritis, providing a unique perspective of the early inflammatory events. An initial aggregation of acute inflammatory cells was noted at the synovial-meniscal junction with maximal numbers observed between 12 and 24 h post challenge. Variations in cell surface ruffling, which may represent different phases of activation, were observed throughout the Arthus response. By 48 h post challenge the meniscal and synovial surfaces were covered by a mat of fibrin and degraded cell remnants.