GSK, Siena, Italy.
Hannover Medical School, institute of virology, Hannover, Germany.
Sci Rep. 2018 Feb 7;8(1):2593. doi: 10.1038/s41598-018-20609-5.
Group B Streptococcus (GBS) is a normal inhabitant of recto-vaginal mucosae in up to 30% of healthy women. Colonization is a major risk factor for perinatal infection which can lead to severe complications such as stillbirth and neonatal invasive disease. Intra-partum antibiotic prophylaxis in colonized women is a safe and cost-effective preventive measure against early-onset disease in the first days of life, but has no effect on late-onset manifestations or on early maternal infection. Maternal immunization with capsular polysaccharide-based vaccines shows promise for the prevention of both early-onset and late-onset neonatal infections, although ability to prevent maternal colonization and ascending infection has been less studied. Here we investigated the effect of a GBS glycoconjugate vaccine since the very early stage of maternal GBS acquisition to neonatal outcome by rodent models of vaginal colonization and ascending infection. Immunization of female mice and rats with a type III glycoconjugate reduced vaginal colonization, infection of chorioamniotic/ placental membranes and bacterial transmission to fetuses and pups. Type III specific antibodies were detected in the blood and vagina of vaccinated mothers and their offspring. The obtained data support a potential preventive effect of GBS glycoconjugate vaccines during the different stages of pregnancy.
B 组链球菌（GBS）是健康女性中高达 30%的直肠-阴道黏膜的正常寄居菌。定植是围产期感染的主要危险因素，可导致严重并发症，如死产和新生儿侵袭性疾病。对定植女性进行产时抗生素预防是预防生命最初几天内早发性疾病的安全且具有成本效益的预防措施，但对晚发性表现或早期母体感染没有影响。基于荚膜多糖的疫苗对预防早发性和晚发性新生儿感染具有一定的前景，尽管预防母体定植和上行感染的能力研究较少。在这里，我们通过阴道定植和上行感染的啮齿动物模型，研究了 GBS 糖缀合物疫苗在母体 GBS 获得的早期阶段对新生儿结局的影响。用 III 型糖缀合物对雌性小鼠和大鼠进行免疫接种可减少阴道定植、绒毛膜羊膜炎/胎盘膜感染以及细菌向胎儿和幼崽的传播。在接种疫苗的母亲及其后代的血液和阴道中检测到 III 型特异性抗体。获得的数据支持 GBS 糖缀合物疫苗在妊娠的不同阶段具有潜在的预防作用。
