Kim Kwang Hyun, Lee Hyung Ho, Yoon Young Eun, Na Joon Chae, Kim Sook Young, Cho Young In, Hong Sung Joon, Han Woong Kyu
Department of Urology, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
Department of Medicine, The Graduate School of Yonsei University, Seoul, Republic of Korea.
Oncotarget. 2017 Dec 10;9(1):662-667. doi: 10.18632/oncotarget.23087. eCollection 2018 Jan 2.
To determine the suitability of serum endocan (ESM-1) levels for diagnosing and monitoring renal cell carcinoma (RCC), we measure serum ESM-1 levels in 56 RCC patients who had undergone radical or partial nephrectomies and 56 age- and sex-matched healthy kidney donors. Measurements were made before and 1 month and 3 months after surgery. The areas under the curve (AUCs) were determined from receiver operating characteristic (ROC) analyses. RCC patients had higher mean serum ESM-1 levels than control subjects (0.59 ± 0.07 vs. 0.52 ± 0.08 ng/mL, < 0.001), with an AUC of 0.721 (95% CI: 0.628-0.817). In patients with tumors larger than 2 cm ( = 40) and those with clear-cell histology ( = 44), the AUCs for ESM-1 were 0.771 and 0.721, respectively. In control subjects, serum ESM-1 levels were higher in older (>50 years) individuals ( < 0.001). Among the study cohort, the AUCs for ESM-1 were 0.813 in individuals 50 years of age or younger ( = 55) and 0.637 in individuals older than 50 years ( = 57). In RCC patients, serum ESM-1 levels were reduced 1 month ( = 0.047) and 3 months ( = 0.009) after surgery. These results suggest serum ESM-1 can serve as a serologic biomarker for diagnosing and monitoring RCC, particularly in patients younger than 50 years.
为了确定血清内抑素（内皮细胞特异性分子-1，ESM-1）水平用于诊断和监测肾细胞癌（RCC）的适用性，我们检测了56例接受根治性或部分肾切除术的RCC患者以及56例年龄和性别匹配的健康肾脏供体的血清ESM-1水平。检测在手术前、术后1个月和3个月进行。通过受试者工作特征（ROC）分析确定曲线下面积（AUC）。RCC患者的血清ESM-1平均水平高于对照组（0.59±0.07 vs. 0.52±0.08 ng/mL，P<0.001），AUC为0.721（95%CI：0.628 - 0.817）。在肿瘤大于2 cm的患者（n = 40）和透明细胞组织学类型的患者（n = 44）中，ESM-1的AUC分别为0.771和0.721。在对照组中，年龄大于50岁的个体血清ESM-1水平较高（P<0.001）。在研究队列中，50岁及以下个体（n = 55）中ESM-1的AUC为0.813，50岁以上个体（n = 57）中为0.637。在RCC患者中，术后1个月（P = 0.047）和3个月（P = 0.009）血清ESM-1水平降低。这些结果表明血清ESM-1可作为诊断和监测RCC的血清生物标志物，尤其是在50岁以下的患者中。
