Erman Hande, Beydogan Engin, Cetin Seher Irem, Boyuk Banu
Department of Internal Medicine, SBU Fatih Sultan Mehmet Education and Research Hospital, Turkey.
Department of Radiology, SBU Taksim Education and Research Hospital, Turkey.
Mediators Inflamm. 2020 Apr 1;2020:3534042. doi: 10.1155/2020/3534042. eCollection 2020.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, which has recently been mentioned as an independent cardiovascular risk factor.
Endocan is a novel molecule of endothelial dysfunction. We aimed to evaluate the associations of serum endocan levels with the hepatic steatosis index (HSI), fatty liver index (FLI), and degrees of hepatosteatosis in patients with metabolic syndrome with NAFLD. . This cross-sectional prospective study was performed in the outpatient clinic of an internal medicine department.
The study included 40 patients with metabolic syndrome with NAFLD as noted using hepatic ultrasound and 20 healthy controls. Secondary causes of fatty liver were excluded. FLI and HSI calculations were recorded. Serum endocan level values were obtained after overnight fasting.
Higher values of HSI and FLI were found in the NAFLD groups than in the control groups ( < 0.001). Five (12.5%) of 20 patients with liver steatosis had grade 1 liver steatosis, 15 (37.5%) patients had grade 2 liver steatosis, and 20 (50%) patients had grade 3 liver steatosis. Serum endocan levels were lower in patients with NAFLD compared with the healthy controls (146.56 ± 133.29 pg/mL vs. 433.71 ± 298.01 pg/mL, < 0.001). ROC curve analysis suggested that the optimum endocan value cutoff point for NAFLD was 122.583 pg/mL (sensitivity: 71.79%, specificity: 90%, PPV: 93.3%, and NPV: 62.1%).
Serum endocan concentrations are low in patients with NAFLD, and the optimum cutoff point is 122.583 pg/mL. HSI and FLI were higher in patients with NAFLD; however, there was no correlation with serum endocan.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝病之一，最近被提及为一种独立的心血管危险因素。
内脂素是一种内皮功能障碍的新型分子。我们旨在评估代谢综合征合并NAFLD患者血清内脂素水平与肝脂肪变指数（HSI）、脂肪肝指数（FLI）及肝脂肪变程度之间的关联。本横断面前瞻性研究在内科门诊进行。
该研究纳入了40例经肝脏超声检查确诊为代谢综合征合并NAFLD的患者及20例健康对照。排除脂肪肝的继发原因。记录FLI和HSI的计算结果。过夜禁食后获取血清内脂素水平值。
NAFLD组的HSI和FLI值高于对照组（<0.001）。20例肝脂肪变患者中，5例（12.5%）为1级肝脂肪变，15例（37.5%）为2级肝脂肪变，20例（50%）为3级肝脂肪变。与健康对照相比，NAFLD患者的血清内脂素水平较低（146.56±133.29 pg/mL对433.71±298.01 pg/mL，<0.001）。ROC曲线分析表明，NAFLD的最佳内脂素值截断点为122.583 pg/mL（敏感性：71.79%，特异性：90%，阳性预测值：93.3%，阴性预测值：62.1%）。
NAFLD患者血清内脂素浓度较低，最佳截断点为122.583 pg/mL。NAFLD患者的HSI和FLI较高；然而，与血清内脂素无相关性。
