Lowey S
Med Sci Sports Exerc. 1986 Jun;18(3):284-91. doi: 10.1249/00005768-198606000-00006.
Skeletal muscles, unlike cardiac tissue, express several myosin isozymes during development which differ in primary structure from adult myosin. Monoclonal antibodies have shown the presence of at least two embryonic myosins, followed by a post-hatch myosin that persists until the appearance of adult myosin in chicken pectoralis muscle. Although the two major cardiac isozymes differ in enzymatic activity, the avian skeletal myosin isozymes all share the same high level of ATPase activity found for adult pectoralis myosin. The functional basis for the extensive myosin polymorphism in skeletal muscles thus remains to be determined.
与心肌组织不同，骨骼肌在发育过程中表达几种肌球蛋白同工酶，其一级结构与成年肌球蛋白不同。单克隆抗体显示鸡胸肌中至少存在两种胚胎肌球蛋白，随后是孵化后的肌球蛋白，这种肌球蛋白一直持续到成年肌球蛋白出现。虽然两种主要的心肌同工酶在酶活性上有所不同，但禽类骨骼肌肌球蛋白同工酶都具有与成年胸肌肌球蛋白相同的高水平ATP酶活性。因此，骨骼肌中广泛存在的肌球蛋白多态性的功能基础仍有待确定。
