探索与睾丸生殖细胞肿瘤相关的分子层面：综述
Exploring the molecular aspects associated with testicular germ cell tumors: a review.
作者信息
Facchini Gaetano, Rossetti Sabrina, Cavaliere Carla, D'Aniello Carmine, Di Franco Rossella, Iovane Gelsomina, Grimaldi Giovanni, Piscitelli Raffaele, Muto Paolo, Botti Gerardo, Perdonà Sisto, Veneziani Bianca Maria, Berretta Massimiliano, Montanari Micaela
机构信息
Progetto ONCONET2.0, Linea Progettuale 14 per l'Implementazione della Prevenzione e Diagnosi Precoce del Tumore alla Prostata e Testicolo, Regione Campania, Italy.
S.S.D Oncologia Clinica Sperimentale Uro-Andrologica, Dipartimento Corp-S Assistenziale dei Percorsi Oncologici Uro-Genitale, Istituto Nazionale Tumori "Fondazione G. Pascale", IRCCS, Naples, Italy.
出版信息
Oncotarget. 2017 Nov 3;9(1):1365-1379. doi: 10.18632/oncotarget.22373. eCollection 2018 Jan 2.
Testicular germ cell tumors (TGCTs) represent the most common solid tumors affecting young men. They constitute a distinct entity because of their embryonic origin and their unique biological behavior. Recent preclinical data regarding biological signaling machinery as well as genetic and epigenetic mechanisms associated with molecular patterns of tumors have contribute to explain the pathogenesis and the differentiation of TGCTs and to understand the mechanisms responsible for the development of resistance to treatment. In this review, we discuss the main genetic and epigenetic events associated with TGCTs development in order to better define their role in the pathogenesis of these tumors and in cisplatin-acquired resistance.
睾丸生殖细胞肿瘤（TGCTs）是影响年轻男性的最常见实体瘤。由于其胚胎起源和独特的生物学行为，它们构成了一个独特的实体。最近关于生物信号传导机制以及与肿瘤分子模式相关的遗传和表观遗传机制的临床前数据，有助于解释TGCTs的发病机制和分化，并理解导致治疗耐药性发展的机制。在这篇综述中，我们讨论了与TGCTs发展相关的主要遗传和表观遗传事件，以便更好地确定它们在这些肿瘤发病机制和顺铂获得性耐药中的作用。
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