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长链非编码RNA n326322促进鼻咽癌的增殖和侵袭。

Long non-coding RNA n326322 promotes the proliferation and invasion in nasopharyngeal carcinoma.

作者信息

Du Mingyu, Huang Teng, Wu Jing, Gu Jia-Jia, Zhang Nan, Ding Kai, Qian Lu-Xi, Lu Zhi-Wei, Zhang Wen-Jun, Tian Xiao-Kang, He Xia, Yin Li

机构信息

Xuzhou Medical University, Xuzhou, Jiangsu, China.

Jiangsu Cancer Hospital and Jiangsu Institue of Cancer Research and Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China.

出版信息

Oncotarget. 2017 Dec 1;9(2):1843-1851. doi: 10.18632/oncotarget.22828. eCollection 2018 Jan 5.

DOI:10.18632/oncotarget.22828
PMID:29416735
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5788603/
Abstract

Long non-coding RNAs (lncRNAs) have been reported to perform significant roles in cancer development and progression. Our research has found that a novel lncRNA n326322 was higher in nasopharyngeal carcinoma (NPC) cells. Moreover, the gain and loss of functional approaches revealed that the overexpression of lncRNA-n326322 promoted NPC cell proliferation and invasion, whereas the downregulation of lncRNA-n326322 suppressed cell proliferation and invasion. Further experiments demonstrated that potential mechanism may be associated with the activation of PI3K/AKT and ERK/MAPK pathways. Taken together, these results indicate that lncRNA-n326322 is associated with tumorigenesis of NPC.

摘要

据报道，长链非编码RNA（lncRNAs）在癌症的发生和发展中发挥着重要作用。我们的研究发现，一种新型lncRNA n326322在鼻咽癌（NPC）细胞中表达较高。此外，功能获得和缺失实验表明，lncRNA-n326322的过表达促进了NPC细胞的增殖和侵袭，而lncRNA-n326322的下调则抑制了细胞的增殖和侵袭。进一步的实验表明，潜在机制可能与PI3K/AKT和ERK/MAPK信号通路的激活有关。综上所述，这些结果表明lncRNA-n326322与NPC的肿瘤发生有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/36c8c20045bc/oncotarget-09-1843-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/0e7871414f6c/oncotarget-09-1843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/acb65696452a/oncotarget-09-1843-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/379e57c35a4b/oncotarget-09-1843-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/36c8c20045bc/oncotarget-09-1843-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/0e7871414f6c/oncotarget-09-1843-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/acb65696452a/oncotarget-09-1843-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/379e57c35a4b/oncotarget-09-1843-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08b8/5788603/36c8c20045bc/oncotarget-09-1843-g004.jpg

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Oncogenic drives invasion and maintains metastases in colorectal cancer.
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