• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

LINC00461，一种长链非编码RNA，对胶质瘤细胞的增殖和迁移很重要。

LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells.

作者信息

Yang Yali, Ren Mingxin, Song Chao, Li Dan, Soomro Shahid Hussain, Xiong Yajie, Zhang Hongfeng, Fu Hui

机构信息

Department of Anatomy and Embryology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.

Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430014, China.

出版信息

Oncotarget. 2017 Aug 18;8(48):84123-84139. doi: 10.18632/oncotarget.20340. eCollection 2017 Oct 13.

DOI:10.18632/oncotarget.20340
PMID:29137410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5663582/
Abstract

An increasing number of reports have revealed that long non-coding RNAs are important players in tumorigenesis. Here we showed that long non-coding RNA LINC00461 is highly expressed in glioma tissues compared to non-neoplastic brain tissues. The knockdown of LINC00461 suppressed cyclinD1/A/E expression which led to G0/G1 cell cycle arrest and inhibited cell proliferation in glioma cells. LINC00461 suppression also inhibited glioma cell migration and invasion. The function of LINC00461 in glioma cells is partially mediated by MAPK/ERK and PI3K/AKT signaling pathways as down-regulation of LINC00461 expression suppressed ERK1/2 and AKT activities. Moreover, LINC00461 knockdown decreased expression levels of microRNA miR-9 and flanking genes and Taken together, our results demonstrate that LINC00461 is important for glioma progression affecting cell proliferation, migration and invasion via MAPK/ERK, PI3K/AKT, and possibly other signaling pathways.

摘要

越来越多的报告显示，长链非编码RNA在肿瘤发生过程中起着重要作用。在此我们表明，与非肿瘤性脑组织相比，长链非编码RNA LINC00461在胶质瘤组织中高表达。敲低LINC00461可抑制细胞周期蛋白D1/A/E的表达，导致G0/G1期细胞周期阻滞，并抑制胶质瘤细胞的增殖。LINC00461的抑制还可抑制胶质瘤细胞的迁移和侵袭。LINC00461在胶质瘤细胞中的功能部分由MAPK/ERK和PI3K/AKT信号通路介导，因为LINC00461表达的下调会抑制ERK1/2和AKT的活性。此外，敲低LINC00461会降低微小RNA miR-9及其侧翼基因的表达水平。综上所述，我们的结果表明，LINC00461通过MAPK/ERK、PI3K/AKT以及可能的其他信号通路影响细胞增殖、迁移和侵袭，对胶质瘤进展至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/3d17a4686dc1/oncotarget-08-84123-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/c07c78296353/oncotarget-08-84123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/ef299c79f16c/oncotarget-08-84123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/10da6d8528d4/oncotarget-08-84123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/bc393997f8c9/oncotarget-08-84123-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/e1b2dc437492/oncotarget-08-84123-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/f4f11ae65dba/oncotarget-08-84123-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/3ea0661fa3e5/oncotarget-08-84123-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/3d17a4686dc1/oncotarget-08-84123-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/c07c78296353/oncotarget-08-84123-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/ef299c79f16c/oncotarget-08-84123-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/10da6d8528d4/oncotarget-08-84123-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/bc393997f8c9/oncotarget-08-84123-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/e1b2dc437492/oncotarget-08-84123-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/f4f11ae65dba/oncotarget-08-84123-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/3ea0661fa3e5/oncotarget-08-84123-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b07/5663582/3d17a4686dc1/oncotarget-08-84123-g008.jpg

相似文献

1
LINC00461, a long non-coding RNA, is important for the proliferation and migration of glioma cells.LINC00461，一种长链非编码RNA，对胶质瘤细胞的增殖和迁移很重要。
Oncotarget. 2017 Aug 18;8(48):84123-84139. doi: 10.18632/oncotarget.20340. eCollection 2017 Oct 13.
2
Inhibition of lncRNA LINC00461/miR-216a/aquaporin 4 pathway suppresses cell proliferation, migration, invasion, and chemoresistance in glioma.lncRNA LINC00461/miR-216a/水通道蛋白4通路的抑制可抑制胶质瘤细胞的增殖、迁移、侵袭和化疗耐药性。
Open Life Sci. 2020 Jul 27;15(1):532-543. doi: 10.1515/biol-2020-0048. eCollection 2020.
3
Emerging role of LINC00461 in cancer.LINC00461 在癌症中的新兴作用。
Biomed Pharmacother. 2022 Aug;152:113239. doi: 10.1016/j.biopha.2022.113239. Epub 2022 Jun 6.
4
LINC00461 promotes bladder cancer cells EMT through miR-518b/HNRNPUL1 axis.LINC00461通过miR-518b/HNRNPUL1轴促进膀胱癌细胞上皮-间质转化。
Discov Oncol. 2024 Sep 10;15(1):419. doi: 10.1007/s12672-024-01294-5.
5
Overexpression Can Induce Docetaxel Resistance in Breast Cancer by Interacting with miR-411-5p.过表达可通过与miR-411-5p相互作用诱导乳腺癌对多西他赛耐药。
Onco Targets Ther. 2020 Jun 12;13:5551-5562. doi: 10.2147/OTT.S247776. eCollection 2020.
6
A Long Noncoding RNA ZEB1-AS1 Promotes Tumorigenesis and Predicts Poor Prognosis in Glioma.长链非编码RNA ZEB1-AS1促进胶质瘤的肿瘤发生并预示不良预后。
Int J Mol Sci. 2016 Aug 30;17(9):1431. doi: 10.3390/ijms17091431.
7
Exosome-transmitted LINC00461 promotes multiple myeloma cell proliferation and suppresses apoptosis by modulating microRNA/BCL-2 expression.外泌体传递的 LINC00461 通过调节 microRNA/BCL-2 的表达促进多发性骨髓瘤细胞增殖并抑制细胞凋亡。
Cytotherapy. 2019 Jan;21(1):96-106. doi: 10.1016/j.jcyt.2018.10.006. Epub 2018 Nov 5.
8
Silencing of long non-coding RNA SBDSP1 suppresses tumor growth and invasion in colorectal cancer.长链非编码RNA SBDSP1的沉默抑制结直肠癌的肿瘤生长和侵袭。
Biomed Pharmacother. 2017 Jan;85:355-361. doi: 10.1016/j.biopha.2016.11.036. Epub 2016 Nov 24.
9
Long non-coding RNA ENST00462717 suppresses the proliferation, survival, and migration by inhibiting MDM2/MAPK pathway in glioma.长链非编码RNA ENST00462717通过抑制胶质瘤中的MDM2/MAPK途径来抑制细胞增殖、存活和迁移。
Biochem Biophys Res Commun. 2017 Apr 1;485(2):513-521. doi: 10.1016/j.bbrc.2017.02.015. Epub 2017 Feb 9.
10
Long Noncoding RNA HOXA11-AS Functions as miRNA Sponge to Promote the Glioma Tumorigenesis Through Targeting miR-140-5p.长链非编码RNA HOXA11-AS作为miRNA海绵，通过靶向miR-140-5p促进胶质瘤的肿瘤发生。
DNA Cell Biol. 2017 Oct;36(10):822-828. doi: 10.1089/dna.2017.3805. Epub 2017 Aug 23.

引用本文的文献

1
INSTINCT: Multi-sample integration of spatial chromatin accessibility sequencing data via stochastic domain translation.INSTINCT：通过随机结构域翻译对空间染色质可及性测序数据进行多样本整合。
Nat Commun. 2025 Feb 1;16(1):1247. doi: 10.1038/s41467-025-56535-0.
2
Non-coding RNAs and Aquaporin 4: Their Role in the Pathogenesis of Neurological Disorders.非编码RNA与水通道蛋白4：它们在神经系统疾病发病机制中的作用
Neurochem Res. 2024 Mar;49(3):583-596. doi: 10.1007/s11064-023-04067-8. Epub 2023 Dec 19.
3
LINC01082 Inhibits Non-Small Cell Lung Cancer by Targeting the miR-543/TNRC6A Axis.

本文引用的文献

1
NF-κB Signaling in Gastric Cancer.胃癌中的核因子-κB信号传导
Toxins (Basel). 2017 Mar 28;9(4):119. doi: 10.3390/toxins9040119.
2
Propofol inhibits invasion and growth of ovarian cancer cells via regulating miR-9/NF-κB signal.丙泊酚通过调节miR-9/NF-κB信号通路抑制卵巢癌细胞的侵袭和生长。
Braz J Med Biol Res. 2016 Dec 12;49(12):e5717. doi: 10.1590/1414-431X20165717.
3
Targeting SOX2 as a Therapeutic Strategy in Glioblastoma.靶向SOX2作为胶质母细胞瘤的一种治疗策略
LINC01082 通过靶向 miR-543/TNRC6A 轴抑制非小细胞肺癌。
Biochem Genet. 2023 Aug;61(4):1585-1605. doi: 10.1007/s10528-022-10313-5. Epub 2023 Jan 31.
4
Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders.非编码 RNA 在海马神经发生中的调控作用及相关疾病的潜在治疗靶点。
Biomolecules. 2022 Dec 22;13(1):18. doi: 10.3390/biom13010018.
5
The role of aquaporin 4 in brain tumors: implications for pathophysiology, diagnosis and therapy.水通道蛋白 4 在脑肿瘤中的作用：对病理生理学、诊断和治疗的影响。
Mol Biol Rep. 2022 Nov;49(11):10609-10615. doi: 10.1007/s11033-022-07656-y. Epub 2022 Jun 17.
6
Long noncoding RNAs (lncRNAs) in human lymphomas.人类淋巴瘤中的长链非编码RNA（lncRNAs）
Genes Dis. 2021 Feb 12;9(4):900-914. doi: 10.1016/j.gendis.2021.02.001. eCollection 2022 Jul.
7
Mesenchymal Stem Cells Inhibit the Effects of Dexamethasone in Multiple Myeloma Cells.间充质干细胞抑制地塞米松在多发性骨髓瘤细胞中的作用。
Stem Cells Int. 2022 Apr 4;2022:4855517. doi: 10.1155/2022/4855517. eCollection 2022.
8
Analysis of lncRNA sequences: FAM3D-AS1, LINC01230, LINC01315 and LINC01468 in endometrial cancer.分析长链非编码 RNA 序列：FAM3D-AS1、LINC01230、LINC01315 和 LINC01468 在子宫内膜癌中的作用。
BMC Cancer. 2022 Mar 29;22(1):343. doi: 10.1186/s12885-022-09426-2.
9
Therapy-resistant and -sensitive lncRNAs, SNHG1 and UBL7-AS1 promote glioblastoma cell proliferation.耐药性和敏感性长链非编码 RNA，SNHG1 和 UBL7-AS1 促进脑胶质母细胞瘤细胞增殖。
Oxid Med Cell Longev. 2022 Mar 11;2022:2623599. doi: 10.1155/2022/2623599. eCollection 2022.
10
HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells.组蛋白去乙酰化酶 6 参与调节长链非编码 RNA-微小 RNA-信使 RNA 网络，促进神经胶质瘤细胞的增殖。
J Exp Clin Cancer Res. 2022 Feb 2;41(1):47. doi: 10.1186/s13046-022-02257-w.
Front Oncol. 2016 Oct 24;6:222. doi: 10.3389/fonc.2016.00222. eCollection 2016.
4
Glioblastoma: Overview of Disease and Treatment.胶质母细胞瘤：疾病与治疗概述
Clin J Oncol Nurs. 2016 Oct 1;20(5 Suppl):S2-8. doi: 10.1188/16.CJON.S1.2-8.
5
miR-9 Acts as an OncomiR in Prostate Cancer through Multiple Pathways That Drive Tumour Progression and Metastasis.miR-9 通过多种驱动肿瘤进展和转移的途径在前列腺癌中发挥癌基因作用。
PLoS One. 2016 Jul 22;11(7):e0159601. doi: 10.1371/journal.pone.0159601. eCollection 2016.
6
Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells.雄激素诱导的长链非编码RNA（lncRNA）SOCS2-AS1促进前列腺癌细胞生长并抑制其凋亡。
J Biol Chem. 2016 Aug 19;291(34):17861-80. doi: 10.1074/jbc.M116.718536. Epub 2016 Jun 24.
7
Transcription factor 3 controls cell proliferation and migration in glioblastoma multiforme cell lines.转录因子3控制多形性胶质母细胞瘤细胞系中的细胞增殖和迁移。
Biochem Cell Biol. 2016 Jun;94(3):247-55. doi: 10.1139/bcb-2015-0162. Epub 2016 Feb 22.
8
Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma.新型微小RNA-9靶标的全面分析以及微小RNA-9通过靶向胰岛素样生长因子2 mRNA结合蛋白1在肝细胞癌中的肿瘤抑制作用。
Oncotarget. 2015 Dec 8;6(39):42040-52. doi: 10.18632/oncotarget.5969.
9
Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143.长链非编码RNA UCA1通过下调抑癌性miR-143来调控乳腺癌细胞的生长和凋亡。
Eur Rev Med Pharmacol Sci. 2015 Sep;19(18):3403-11.
10
PI3K and AKT: Unfaithful Partners in Cancer.PI3K与AKT：癌症中的“不忠伙伴”
Int J Mol Sci. 2015 Sep 3;16(9):21138-52. doi: 10.3390/ijms160921138.