脱水诱导的布拉特洛维大鼠心房利钠因子分泌变化：饮水的影响。

Dehydration-induced changes in the secretion of atrial natriuretic factor in Brattleboro rats: effect of water-drinking.

作者信息

Januszewicz P, Gutkowska J, Thibault G, Garcia R, Mercure C, Jolicoeur F, Genest J, Cantin M

出版信息

Neurosci Lett. 1986 Jun 18;67(2):203-7. doi: 10.1016/0304-3940(86)90398-8.

Abstract

The secretion of atrial natriuretic factor (ANF) was measured in Brattleboro rats (DI) subjected to 20-h dehydration and in normal Long-Evans rats (LE) subjected to 72-h dehydration and 7 times within the hour following voluntary rehydration by drinking water. In these rats, water deprivation caused a large, significant drop in plasma immunoreactive ANF (IR-ANF). Drinking water did not restore plasma IR-ANF values within one hour, even when indirect indices of intravascular volume such as serum osmolality, sodium and hematocrit returned to normal. The dehydration-induced decrease in plasma IR-ANF and its very low secretion after restoring drinking may be essential for the homeostasis of water conservation in both DI and LE rats.

摘要

对遭受20小时脱水的布拉特洛维大鼠（DI）以及遭受72小时脱水并在自愿饮水复水后一小时内进行7次测量的正常长 Evans 大鼠（LE），测量了心房利钠因子（ANF）的分泌。在这些大鼠中，禁水导致血浆免疫反应性ANF（IR-ANF）大幅显著下降。即使血清渗透压、钠和血细胞比容等血管内容量间接指标恢复正常，饮水在一小时内也未能使血浆IR-ANF值恢复。脱水引起的血浆IR-ANF下降及其复水后极低的分泌可能对DI和LE大鼠的节水稳态至关重要。