Department of Mechanical Engineering, University of Ottawa, E155D, 200 Lees Avenue, Ottawa, ON, K1N 6N5, Canada.
Department of Mechanical Engineering, University of Ottawa, A214, Colonel By Hall, 161 Louis Pasteur, Ottawa, ON, K1N 6N5, Canada.
Ann Biomed Eng. 2018 May;46(5):726-735. doi: 10.1007/s10439-018-1989-7. Epub 2018 Feb 7.
Transperineal ultrasound (TPUS) allows for objective quantification of mid-sagittal urogenital mechanics, yet current practice omits dynamic motion information in favor of analyzing only a rest and a peak motion frame. This work details the development of UROKIN, a semi-automated software which calculates kinematic curves of urogenital landmark motion. A proof of concept analysis, performed using UROKIN on TPUS video recorded from 20 women with and 10 women without stress urinary incontinence (SUI) performing maximum voluntary contraction of the pelvic floor muscles. The anorectal angle and bladder neck were tracked while the motion of the pubic symphysis was used to compensate for the error incurred by TPUS probe motion during imaging. Kinematic curves of landmark motion were generated for each video and curves were smoothed, time normalized, and averaged within groups. Kinematic data yielded by the UROKIN software showed statistically significant differences between women with and without SUI in terms of magnitude and timing characteristics of the kinematic curves depicting landmark motion. Results provide insight into the ways in which UROKIN may be useful to study differences in pelvic floor muscle contraction mechanics between women with and without SUI and other pelvic floor disorders. The UROKIN software improves on methods described in the literature and provides unique capacity to further our understanding of urogenital biomechanics.
经会阴超声（TPUS）可客观量化中矢状面泌尿生殖力学，但目前的实践省略了动态运动信息，而仅分析静止和峰值运动帧。本工作详细介绍了 UROKIN 的开发，这是一种半自动化软件，可计算泌尿生殖标志运动的运动曲线。使用 UROKIN 对 20 名压力性尿失禁（SUI）女性和 10 名无压力性尿失禁女性进行最大自愿收缩骨盆底肌肉时记录的 TPUS 视频进行了概念验证分析。在对肛门直肠角度和膀胱颈进行跟踪的同时，耻骨联合的运动用于补偿成像过程中 TPUS 探头运动引起的误差。为每个视频生成了标志运动的运动曲线，并对曲线进行平滑处理、时间归一化，并在组内平均。UROKIN 软件生成的运动数据在描述标志运动的运动曲线的幅度和时间特征方面显示出 SUI 女性与无 SUI 女性之间存在统计学显著差异。结果深入了解 UROKIN 可能有助于研究 SUI 和其他盆底障碍女性之间盆底肌肉收缩力学差异的方法。UROKIN 软件改进了文献中描述的方法，并提供了进一步了解泌尿生殖生物力学的独特能力。
