School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing 400016, China.
Center for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing 400016, China.
Nutrients. 2018 Feb 8;10(2):185. doi: 10.3390/nu10020185.
Multiple epidemiologic studies have evaluated the relationship between dietary cholesterol and lung cancer risk, but the association is controversial and inconclusive. A meta-analysis of case-control studies and cohort studies was conducted to evaluate the relationship between dietary cholesterol intake and lung cancer risk in this study. A relevant literature search up to October 2017 was performed in Web of Science, PubMed, China National Knowledge Infrastructure, Sinomed, and VIP Journal Integration Platform. Ten case-control studies and six cohort studies were included in the meta-analysis, and the risk estimates were pooled using either fixed or random effects models. The case-control studies with a total of 6894 lung cancer cases and 29,736 controls showed that dietary cholesterol intake was positively associated with lung cancer risk (Odds Ratio = 1.70, 95% Confidence Interval: 1.43-2.03). However, there was no evidence of an association between dietary cholesterol intake and risk of lung cancer among the 241,920 participants and 1769 lung cancer cases in the cohort studies (Relative Risk = 1.08, 95% Confidence Interval: 0.94-1.25). Due to inconsistent results from case-control and cohort studies, it is difficult to draw any conclusion regarding the effects of dietary cholesterol intake on lung cancer risk. Carefully designed and well-conducted cohort studies are needed to identify the association between dietary cholesterol and lung cancer risk.
多项流行病学研究评估了膳食胆固醇与肺癌风险之间的关系，但关联存在争议且尚无定论。本研究对病例对照研究和队列研究进行了荟萃分析，以评估膳食胆固醇摄入与肺癌风险之间的关系。截至 2017 年 10 月，在 Web of Science、PubMed、中国知网、Sinomed 和 VIP 期刊整合平台上进行了相关文献检索。荟萃分析纳入了 10 项病例对照研究和 6 项队列研究，使用固定效应模型或随机效应模型汇总风险估计值。共纳入 6894 例肺癌病例和 29736 例对照的病例对照研究表明，膳食胆固醇摄入与肺癌风险呈正相关（比值比=1.70，95%置信区间：1.43-2.03）。然而，在 241920 名参与者和 1769 例肺癌病例的队列研究中，没有证据表明膳食胆固醇摄入与肺癌风险之间存在关联（相对风险=1.08，95%置信区间：0.94-1.25）。由于病例对照研究和队列研究的结果不一致，很难得出关于膳食胆固醇摄入对肺癌风险影响的任何结论。需要精心设计和良好实施的队列研究来确定膳食胆固醇与肺癌风险之间的关联。
