Narayana Nethralaya Eye Hospital , Bangalore , India.
GROW Research Laboratory, Narayana Nethralaya Foundation , Bangalore , India.
Ocul Immunol Inflamm. 2019;27(7):1033-1040. doi: 10.1080/09273948.2017.1421232. Epub 2018 Feb 8.
: To determine aqueous humor CD4+/CD8+ T-lymphocyte ratio changes in sarcoid and non-sarcoid uveitis with anterior chamber involvement. : The case-control study includes 61 patients with either anterior uveitis, intermediate uveitis with anterior spill, or panuveitis. A total of 21 of them were categorized as sarcoid uveitis and 40 as non-sarcoid uveitis according to diagnostic criteria. CD4+/CD8+ ratio in the aqueous humor was determined using flow cytometry. : Significantly higher CD4+/CD8+ ratio in the aqueous humor was observed in patients with sarcoid uveitis (6.3 ± 1.4; mean ± SEM) compared to non-sarcoid uveitis (1.6 ± 0.1; mean ± SEM). Whole blood CD4+/CD8+ ratio was not elevated in subjects with sarcoid and non-sarcoid uveitis. Aqueous humor CD4+/CD8+ ratio >3.5 was observed to be associated with sarcoid uveitis (OR 38, 95% CI 7.0-205.2). : Increased aqueous humor CD4+/CD8+ ratio in sarcoid uveitis. Immunophenotyping of localized lymphocytosis in aqueous humor could be utilized as an additional confirmatory marker for ocular sarcoidosis.
: 目的：确定伴有前房受累的类肉瘤和非类肉瘤前葡萄膜炎的房水中 CD4+/CD8+T 淋巴细胞比值的变化。: 这项病例对照研究纳入了 61 例前葡萄膜炎、前房积血伴中间葡萄膜炎或全葡萄膜炎患者。根据诊断标准，其中 21 例归类为类肉瘤性葡萄膜炎，40 例归类为非类肉瘤性葡萄膜炎。采用流式细胞术测定房水中的 CD4+/CD8+比值。: 类肉瘤性葡萄膜炎患者的房水中 CD4+/CD8+比值明显高于非类肉瘤性葡萄膜炎患者（6.3±1.4；均数±SEM 与 1.6±0.1；均数±SEM）。类肉瘤和非类肉瘤性葡萄膜炎患者的全血 CD4+/CD8+比值并未升高。观察到房水中 CD4+/CD8+比值＞3.5 与类肉瘤性葡萄膜炎相关（OR 38，95%CI 7.0-205.2）。: 类肉瘤性葡萄膜炎患者房水中 CD4+/CD8+比值升高。房水中局部淋巴细胞增多的免疫表型可作为眼类肉瘤病的另一个辅助确诊标志物。
