Department of Internal Medicine, Cochin Hospital, Paris, France.
Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Ocul Immunol Inflamm. 2021 Feb 17;29(2):290-298. doi: 10.1080/09273948.2019.1678647. Epub 2019 Oct 31.
: This study aimed to assess the diagnostic relevance of CD4/CD8 ratio in cerebrospinal fluid (CSF) for the etiological diagnosis work-up of uveitis.: We consecutively included patients who were referred to our department for the diagnostic workup of intermediate and/or posterior uveitis. Etiological diagnoses were established in a blind manner regarding CD4/CD8 ratio.: Fifty-two patients were included. A diagnosis of ocular sarcoidosis was made in 15 (29%) patients, 21% had another determined diagnosis while 50% remained of undetermined origin. Median CD4/CD8 ratio in CSF was 4.57 (IQR 3.39-5.47) in ocular sarcoidosis, 1.74 (1.60-3.18) in uveitis due to other determined cause ( = .008), and 2.83 (2.34-3.54) in those with uveitis of undetermined origin ( = .007). CD4/CD8 ratio >3.23 was associated with a diagnosis of ocular sarcoidosis.: Determination of CD4/CD8 ratio in CSF can be useful for diagnosis work-up since a CD4/CD8 ratio >3.23 in CSF is associated with ocular sarcoidosis.
: 本研究旨在评估脑脊液（CSF）中 CD4/CD8 比值对葡萄膜炎病因诊断的相关性。: 我们连续纳入因中间或后部葡萄膜炎而转诊至我科进行诊断性检查的患者。关于 CD4/CD8 比值，在盲法的情况下建立病因诊断。: 共纳入 52 例患者。15 例（29%）患者被诊断为眼结节病，21%有其他明确诊断，50%仍病因不明。眼结节病患者的 CSF 中 CD4/CD8 比值中位数为 4.57（IQR 3.39-5.47），其他明确病因引起的葡萄膜炎患者为 1.74（1.60-3.18）（ = 0.008），病因不明的葡萄膜炎患者为 2.83（2.34-3.54）（ = 0.007）。CSF 中 CD4/CD8 比值>3.23 与眼结节病的诊断相关。: CSF 中 CD4/CD8 比值的测定对诊断性检查可能有用，因为 CSF 中 CD4/CD8 比值>3.23 与眼结节病有关。
