Góngora Fernando B, Chiriboga-Ponce Rosa F
Hemocentro Nacional de la Cruz Roja. Quito, Ecuador.
Ministerio de Salud Pública del Ecuador. Quito, Ecuador.
Gac Med Mex. 2018;154(1):16-21. doi: 10.24875/GMM.17002738.
The Diego blood group is an irregular blood system which has been involved in cases of hemolytic disease of the newborn and post transfusion reactions, in this system have been identified 22 erythrocyte antigens, among which the pair Di/Di is the most important because those have the most immunogenic potential.
This research aims to determine the frequency of antigen Dia and their respective alloantibody in the Ecuadorian population. Methods: It was performed a simple random sampling in the donor population, being later tested tube agglutination by the presence or absence of the antigen and its alloantibody Di applying gel agglutination technique.
It was observed an antigen prevalence of 25% against a 6.09% of percentage alloimmunization due to Di antigen, without significant differences between men and women and these being independent of the age and origin of the donor, showing that there are some Diego positive cases in Ecuadorian population as probably cases of transfusional alloinmunization or due to fetal-maternal alloinmunization.
The frequency distribution of antigens and alloantibodies from the Diego blood group is almost uniform in the population, due presumably to the high incidence of miscegenation in our country. Therefore it becomes vitally important the implementation of this blood system inside the protocols of irregular antibodies identification in Ecuadorian blood banks.
迭戈血型是一个不规则血型系统，与新生儿溶血病和输血后反应病例有关。在这个系统中已鉴定出22种红细胞抗原，其中Di/Di这一对抗原最为重要，因为它们具有最强的免疫原性潜力。
本研究旨在确定厄瓜多尔人群中Dia抗原及其相应同种抗体的频率。方法：在献血人群中进行简单随机抽样，随后通过凝胶凝集技术检测抗原和同种抗体Di的存在与否，采用试管凝集试验。
观察到抗原患病率为25%，而因Di抗原导致的同种免疫百分比为6.09%，男女之间无显著差异，且与献血者的年龄和来源无关，这表明在厄瓜多尔人群中存在一些迭戈阳性病例，可能是输血性同种免疫或胎儿 - 母体同种免疫的情况。
迭戈血型的抗原和同种抗体在人群中的频率分布几乎均匀，这可能是由于我国混血现象的高发生率。因此，在厄瓜多尔血库的不规则抗体鉴定方案中实施该血型系统变得至关重要。
