Figueroa Dolores
MT(ASCP)SBB, IRL System Specialist, Blood Systems Laboratories, 2424 W. Erie Dr., Tempe, AZ 85282.
Immunohematology. 2013;29(2):73-81.
The Diego blood group system (DI) currently encompasses 22 antigens. Three of the antigens are of high prevalence and the other 19 are of low prevalence. The antigens of the Diego blood group system are carried on the erythroid band 3 protein anion exchanger 1 (AE1), the product of a single gene, SLC4A1 (solute carrier family 4, anion exchanger, member 1). AE1 is a member of a family of three anion exchangers or transporters expressed in a variety of tissues. This protein is involved in carbon dioxide transport from tissues to lungs. It is also found in the kidney,where it is involved in acid secretion. Antibodies to Diego system antigens with the exception of anti-Dia, -Dib, -Wra, -ELO and-DISK do not seem to be of clinical significance for transfusion or of importance in hemolytic disease of the fetus and newborn.
迭戈血型系统（DI）目前包含22种抗原。其中三种抗原具有高频率，另外19种具有低频率。迭戈血型系统的抗原由红系带3蛋白阴离子交换器1（AE1）携带，AE1是单基因SLC4A1（溶质载体家族4，阴离子交换器，成员1）的产物。AE1是在多种组织中表达的三种阴离子交换器或转运蛋白家族的成员。该蛋白参与二氧化碳从组织到肺的运输。它也存在于肾脏中，在那里参与酸分泌。除抗Dia、-Dib、-Wra、-ELO和-DISK外，针对迭戈系统抗原的抗体似乎对输血无临床意义，对胎儿和新生儿溶血病也不重要。
