Dos Santos Caldas Adna, Dos Santos Bruno Costa, Palmeira Maurício Koury, Ribeiro Carvalho Fabiana Regina, de Melo Amaral Carlos Eduardo
Centro Universitário Metropolitano da Amazônia, Belém, PA, Brazil.
Centro Universitário Metropolitano da Amazônia, Belém, PA, Brazil.
Hematol Transfus Cell Ther. 2022 Jul-Sep;44(3):352-357. doi: 10.1016/j.htct.2020.12.007. Epub 2021 Feb 11.
Erythrocyte phenotyping is a very important test in the adoption of prophylactic measures to reduce transfusion reactions/alloimmunizations in polytransfused patients. The blood group Diego, in its current, form has 22 antigens, of which 4 are immunogenic, being Diª/Di and W/W, while the others are less expressive. The antigen Diª is of low incidence among whites and blacks, however, it is common in the South American indigenous and Asian Mongolian populations. It is also considered a system of clinical importance for its immunogenicity.
The present study aimed to carry out a retrospective and descriptive survey of the frequency of the Diª antigen in the blood donor population at the HEMOPA Foundation Coordinating Blood Center from 12/2018 to 1/2000. The data obtained were from the HEMOPA Foundation SBS Progress and SBS WEB Systems databases.
During this period, 941,744 blood bags were collected and, of these, 930 bags were phenotyped for the Diª antigen, of which 842 were negative and 88 (9.7%) positive. The research showed that, among the positive donors for the antigen Diª, 88.6% were brown, 3.4%, black and 8%, white. In the statistical analysis, the frequency observed was higher in browns.
In the present investigation, we concluded that our region has a relatively higher frequency of the Diª antigen, when compared to the rest of Brazil, and it occurs more often in browns.
红细胞表型分析对于采取预防措施以减少多次输血患者的输血反应/同种免疫而言是一项非常重要的检测。迭戈血型目前共有22种抗原，其中4种具有免疫原性，即Diª/Di和W/W，其他抗原的表达性较低。抗原Diª在白人和黑人中发病率较低，但在南美原住民和亚洲蒙古人种群体中较为常见。因其免疫原性，它也被认为是一个具有临床重要性的血型系统。
本研究旨在对2018年12月至2000年1月期间HEMOPA基金会协调血液中心献血人群中Diª抗原的频率进行回顾性描述性调查。所获数据来自HEMOPA基金会的SBS Progress和SBS WEB系统数据库。
在此期间，共采集了941,744袋血液，其中930袋进行了Diª抗原表型分析，842袋为阴性，88袋（9.7%）为阳性。研究表明，在Diª抗原阳性献血者中，88.6%为棕色人种，3.4%为黑人，8%为白人。统计分析显示，棕色人种中观察到的频率较高。
在本调查中，我们得出结论，与巴西其他地区相比，我们所在地区Diª抗原的频率相对较高，且在棕色人种中出现得更为频繁。
