Department of Specific Formation, School of Dentistry, Fluminense Federal University, Nova Friburgo, Brazil.
Postgraduate Program in Dentistry, Fluminense Federal University, Niterói, Brazil.
Photochem Photobiol. 2018 Jul;94(4):752-759. doi: 10.1111/php.12901. Epub 2018 Apr 6.
The systematic review and meta-analysis were undertaken to evaluate the effectiveness of antimicrobial photodynamic therapy (aPDT) in the microbiological alteration beneficial to peri-implantitis treatment. This study is registered with PROSPERO, number CRD42017064215. Bibliographic databases including Cochrane Library, Web of Science, Scopus and PubMed were searched from inception to 8 January 2017. The search strategy was assembled from the following MeSH Terms: "Photochemotherapy," "Dental Implants" and "Peri-Implantitis." Unspecific free-text words and related terms were also included. The Cochrane Collaboration's tool was used to evaluate the risk of bias of included studies. The random-effect model was chosen, and heterogeneity was evaluated using the I test. Three studies met the inclusion criteria. Meta-analysis demonstrated an association between aPDT and reduction in viable bacteria counts for: Aggregatibacter actinomycetemcomitans (OR = 1.31; confidence interval = 1.13, 1.49; P < 0.00001), Porphyromonas gingivalis (OR = 4.08; confidence interval = 3.22, 4.94; P < 0.00001) and Prevotella intermedia (OR = 1.66; confidence interval = 1.06, 2.26; P < 0.00001). A aPDT appears to be effective in bacterial load reduction in peri-implantitis and has a positive potential as an alternative therapy for peri-implantitis.
系统评价和荟萃分析评估了抗菌光动力疗法（aPDT）在有益于治疗种植体周围炎的微生物变化方面的有效性。本研究已在 PROSPERO 注册，编号为 CRD42017064215。从创建到 2017 年 1 月 8 日，检索了包括 Cochrane 图书馆、Web of Science、Scopus 和 PubMed 在内的文献数据库。检索策略由以下 MeSH 术语组成：“光化学疗法”、“牙种植体”和“种植体周围炎”。还包括了非特定的自由文本词和相关术语。使用 Cochrane 协作工具评估纳入研究的偏倚风险。选择随机效应模型，并使用 I 检验评估异质性。有三项研究符合纳入标准。荟萃分析表明，aPDT 与减少以下细菌数量有关：伴放线放线杆菌（OR = 1.31；置信区间 = 1.13, 1.49；P < 0.00001）、牙龈卟啉单胞菌（OR = 4.08；置信区间 = 3.22, 4.94；P < 0.00001）和中间普氏菌（OR = 1.66；置信区间 = 1.06, 2.26；P < 0.00001）。aPDT 似乎在减少种植体周围炎的细菌负荷方面有效，并且具有作为种植体周围炎替代治疗的积极潜力。
