Pérez-Chaparro Paula Juliana, Duarte Poliana Mendes, Shibli Jamil Awad, Montenegro Sheyla, Lacerda Heluy Sílvia, Figueiredo Luciene Cristina, Faveri Marcelo, Feres Magda
Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos, São Paulo, Brazil.
J Periodontol. 2016 Nov;87(11):1295-1304. doi: 10.1902/jop.2016.160184. Epub 2016 Jul 15.
There is currently no consensus regarding microorganisms that may be considered true peri-implant pathogens. Therefore, the aim of this systematic review is to determine the weight of evidence for microorganisms related to peri-implantitis based on results of association studies.
This review was performed following the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA). Two independent researchers searched PubMed/Medline, Embase, and Cochrane Library databases up to August 4, 2015, for studies comparing microbiologic outcomes of subgingival biofilm samples from healthy implants and implants with peri-implantitis.
A total of 799 titles was identified and 11 studies were included in this review. All data were extracted using a predefined form. Microorganisms found in increased count/abundance/frequency in peri-implantitis belonged to Bacteria domain and viruses, and included a total of six bacterial phyla, 17 bacterial genera, 23 bacterial species, and two genera of viruses. The main bacterial species associated with peri-implantitis are recognized as periodontal pathogens.
Results of this systematic review suggest moderate evidence supporting association of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia and some evidence supporting association of Prevotella intermedia and Campylobacter rectus with the etiology of peri-implantitis.
目前对于可被视为真正的种植体周围病原体的微生物尚无共识。因此，本系统评价的目的是根据关联研究结果确定与种植体周炎相关的微生物的证据权重。
本评价按照系统评价和Meta分析的首选报告项目（PRISMA）进行。两名独立研究人员检索了截至2015年8月4日的PubMed/Medline、Embase和Cochrane图书馆数据库，以查找比较健康种植体和患有种植体周炎的种植体龈下生物膜样本微生物学结果的研究。
共识别出799篇标题，本评价纳入了11项研究。所有数据均使用预定义表格提取。在种植体周炎中数量/丰度/频率增加的微生物属于细菌域和病毒，共包括6个细菌门、17个细菌属、23个细菌种和两个病毒属。与种植体周炎相关的主要细菌种被认为是牙周病原体。
本系统评价结果表明有中等证据支持牙龈卟啉单胞菌、具核梭杆菌和福赛坦氏菌的关联，有一些证据支持中间普氏菌和直肠弯曲菌与种植体周炎病因的关联。
