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[动物实验中箭毒样地阿诺宁和双吡啶鎓制剂的磁控转运研究]

[Study of magnet-controlled transport of curare-like preparations of diadonium and dipyronium in animal experiments].

作者信息

Kharkevich D A, Aliautdin R N, Filippov V I, Nemirovskiĭ A Iu, Kasparov S A

出版信息

Biull Eksp Biol Med. 1986 Jul;102(7):48-9.

PMID:2942196
Abstract

The experiments on cats have shown that liposomes containing ferrocolloid and neuromuscular blocking agents (diadonium or dipyronium) cause selective muscle relaxation in the animal limb placed into the magnetic field, compared to the control limb kept outside the field. This effect was not related to the action of the magnetic field per se on neuromuscular transmission or the potency of neuromuscular blocking agents not contained in liposomes, but was induced by the accumulation of magnet-controlled liposomes in the target limb. The use of magnet-controlled liposomes for diadonium and dipyronium transport to one of the animal limbs decreases their unfavourable effect on respiratory muscle function.

摘要

对猫的实验表明,与置于磁场外的对照肢体相比,含有铁胶体和神经肌肉阻滞剂(二氮䓬或双吡啶䓬)的脂质体可使置于磁场中的动物肢体产生选择性肌肉松弛。这种效应与磁场本身对神经肌肉传递的作用或脂质体中未包含的神经肌肉阻滞剂的效力无关,而是由磁控脂质体在目标肢体中的积累引起的。利用磁控脂质体将二氮䓬和双吡啶䓬输送到动物的一个肢体,可降低它们对呼吸肌功能的不利影响。

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1
[Study of magnet-controlled transport of curare-like preparations of diadonium and dipyronium in animal experiments].[动物实验中箭毒样地阿诺宁和双吡啶鎓制剂的磁控转运研究]
Biull Eksp Biol Med. 1986 Jul;102(7):48-9.
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