Korobov N V, Iavorskiĭ A N
Farmakol Toksikol. 1981 May-Jun;44(3):338-42.
It has been shown in acute experiments on rats, rabbits and cats that under extracorporeal pulmonary ventilation, the animals could tolerate the 50-100 fold apnoeic doses of diadonium. Chronic experiments have demonstrated that administration of the subapnoeic doses of diadonium to rats, rabbits, and dogs and the apnoeic doses to rats (under extracorporeal respiration) for 10-14 days exerts no significant effect on the peripheral blood, the main biochemical characteristics of blood serum, histological structure of the internal organs, and does not possess local irritant or hemolytic action. The data obtained indicate the safety of diadonium as a myorelaxant.
在对大鼠、兔子和猫进行的急性实验中已表明，在体外肺通气情况下，这些动物能够耐受比致呼吸暂停剂量大50至100倍的地阿诺剂量。慢性实验证明，对大鼠、兔子和狗给予低于致呼吸暂停剂量的地阿诺，对大鼠给予致呼吸暂停剂量（在体外呼吸情况下），持续10至14天，对外周血、血清的主要生化特性、内脏的组织结构均无显著影响，且不具有局部刺激或溶血作用。所获数据表明地阿诺作为一种肌松剂是安全的。
