Annweiler Cedric, Doineau Lise, Gerigne Lucie, Provendier Anais, Karras Spyridon N, Beauchet Olivier, Fantino Bruno, Duval Guillaume T
Department of Geriatric Medicine, University Memory Clinic, UPRES EA 4638, Angers University Hospital, Angers, France.
Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, Ontario, Canada.
Curr Alzheimer Res. 2018;15(7):664-670. doi: 10.2174/1567205015666180201153735.
Older adults with hypovitaminosis D report more often subjective cognitive complaints, especially with regards to memory. This raises prospects that vitamin D may improve older adults' subjective experience of memory disorders.
To determine among older community-dwellers whether higher serum 25- hydroxyvitamin D (25OHD) concentrations were associated with fewer memory complaints, while considering different subtypes of memory complaints.
One hundred eighty Caucasian community-dwellers with memory complaint and no dementia (mean±standard deviation, 71.1±3.4years; 33.3%female) from the French 'EVATEM study' were included in this analysis. Subjective memory complaints regarding memory lapses, problems learning new information, problems finding words, problems calculating and problems concentrating were assessed using a standardized questionnaire. Participants were categorized according to the highest tertile of serum 25OHD (i.e., ≥68nmol/L). Age, gender, body mass index, morbidities burden, use of vitamin D supplements, cognitive performance, mood, serum concentrations of calcium, parathyroid hormone and vitamin B12, creatinine clearance, and season of evaluation were used as potential confounders.
Compared to participants with 25OHD<68nmol/L (n=121), those with 25OHD≥68nmol/L had less often problems learning new information (P=0.027). There were no between-group differences for the other memory complaints. The highest 25OHD tertile was cross-sectionally associated with fewer problems learning new information (odds ratio (OR)=0.48, P=0.029), even after adjustment for potential confounders (OR=0.32, P=0.039).
Higher vitamin D status was associated with reduced problems memorizing new information in older community-dwellers. This novel finding provides a scientific base for vitamin D replacement trials attempting to improve older patients' subjective experience of cognitive decline.
维生素D缺乏的老年人更常报告主观认知方面的不适，尤其是在记忆方面。这引发了一种可能性，即维生素D可能改善老年人记忆障碍的主观体验。
在老年社区居民中确定较高的血清25-羟基维生素D（25OHD）浓度是否与较少的记忆不适相关，同时考虑记忆不适的不同亚型。
来自法国“EVATEM研究”的180名有记忆不适且无痴呆的白种社区居民（平均±标准差，71.1±3.4岁；33.3%为女性）纳入本分析。使用标准化问卷评估关于记忆失误、学习新信息困难、找词困难、计算困难和注意力不集中等主观记忆不适情况。参与者根据血清25OHD的最高三分位数（即≥68nmol/L）进行分类。年龄、性别、体重指数、疾病负担、维生素D补充剂的使用、认知表现、情绪、血清钙、甲状旁腺激素和维生素B12浓度、肌酐清除率以及评估季节用作潜在混杂因素。
与25OHD<68nmol/L的参与者（n = 121）相比，25OHD≥68nmol/L的参与者学习新信息困难的情况较少（P = 0.027）。其他记忆不适情况在组间无差异。即使在调整潜在混杂因素后，最高的25OHD三分位数与学习新信息困难较少仍存在横断面关联（优势比（OR）= 0.48，P = 0.029）（OR = 0.32，P = 0.039）。
较高的维生素D水平与老年社区居民记忆新信息困难的减少相关。这一新发现为试图改善老年患者认知衰退主观体验的维生素D替代试验提供了科学依据。
