老年人颅内体积与维生素D相关的变化：一项定量神经影像学研究。
Vitamin D-related changes in intracranial volume in older adults: a quantitative neuroimaging study.
作者信息
Annweiler Cedric, Bartha Robert, Goncalves Sandy, Karras Spyridon N, Millet Pascal, Féron Francois, Beauchet Olivier
机构信息
Department of Geriatric Medicine, Angers University Hospital; UPRES EA4638, University of Angers, UNAM, France; Research Center on Autonomy and Longevity (CeRAL), Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada.
Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada.
出版信息
Maturitas. 2015 Mar;80(3):312-7. doi: 10.1016/j.maturitas.2014.12.011. Epub 2014 Dec 31.
OBJECTIVES
Vitamin D is involved in skeletal and brain health. Recently, serum 25-hydroxyvitamin D (25OHD) concentration was found to be inversely correlated with intracranial volume in younger adults. Since hypovitaminosis D is most common in older adults, our objective was to determine whether this inverse correlation between 25OHD concentration and intracranial volume also occurred in older adults.
STUDY DESIGN
Cross-sectional study.
MAIN OUTCOME MEASURES
One hundred and ten Caucasian older community-dwellers (mean, 71.7±5.7 years; 45.5% female) received a blood test and an MRI of the brain at the same period. The intracranial volume and the subvolumes of cerebrospinal fluid, total brain, infratentorial brain, supratentorial brain, total white matter, total gray matter, cortical gray matter and subcortical gray matter were measured using FreeSurfer volumetry on T1-weighted images. Vitamin D insufficiency was defined as serum 25OHD<50nmol/L. Age, gender, body mass index, education level, use of vitamin D supplements, season of evaluation, serum concentrations of calcium and thyroid stimulating hormone were used as covariables in the analysis.
RESULTS
We found that participants with vitamin D insufficiency (n=41) had greater intracranial volume than those without (1555.0±1379.2cm(3) versus 1488.0±167.4cm(3), P=0.033). Serum 25OHD concentration was cross-sectionally associated with decreased intracranial volume in mm(3) (unadjusted β=-1194.4, P=0.028), even after adjustment for covariables (adjusted β=-994.3, P=0.048). We found an inverse correlation of serum 25OHD with intracranial volume (r=-0.21, P=0.028) and the volume of white matter (r=-0.20, P=0.033). The other subvolumes did not correlate with serum 25OHD concentration.
CONCLUSIONS
Serum 25OHD concentration was independently and inversely associated with intracranial volume in older adults.
目的
维生素D与骨骼和大脑健康有关。最近发现，在较年轻的成年人中，血清25-羟基维生素D（25OHD）浓度与颅内体积呈负相关。由于维生素D缺乏症在老年人中最为常见，我们的目的是确定25OHD浓度与颅内体积之间的这种负相关在老年人中是否也存在。
研究设计
横断面研究。
主要观察指标
110名高加索老年社区居民（平均年龄71.7±5.7岁；女性占45.5%）在同一时期接受了血液检查和脑部MRI检查。使用FreeSurfer容积测量法在T1加权图像上测量颅内体积以及脑脊液、全脑、幕下脑、幕上脑、全白质、全灰质、皮质灰质和皮质下灰质的亚体积。维生素D不足定义为血清25OHD<50nmol/L。年龄、性别、体重指数、教育水平、维生素D补充剂的使用、评估季节、血清钙和促甲状腺激素浓度在分析中用作协变量。
结果
我们发现维生素D不足的参与者（n=41）的颅内体积大于没有维生素D不足的参与者（1555.0±1379.2cm³对1488.0±167.4cm³，P=0.033）。即使在对协变量进行调整后，血清25OHD浓度与以mm³为单位的颅内体积减小呈横断面相关（未调整的β=-1194.4，P=0.028；调整后的β=-994.3，P=0.048）。我们发现血清25OHD与颅内体积（r=-0.21，P=0.028）和白质体积（r=-0.20，P=0.033）呈负相关。其他亚体积与血清25OHD浓度无相关性。
结论
在老年人中，血清25OHD浓度与颅内体积独立且呈负相关。
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