Soutif-Veillon Anne, Ferland Guylaine, Rolland Yves, Presse Nancy, Boucher Kariane, Féart Catherine, Annweiler Cedric
Department of Family Medicine, School of Medicine, University of Angers, UNAM, Angers, France.
Centre de recherche, Institut Universitaire de Gériatrie de Montréal, Montréal, Quebec, Canada.
Maturitas. 2016 Nov;93:131-136. doi: 10.1016/j.maturitas.2016.02.004. Epub 2016 Feb 11.
Increased dietary intake of vitamin K, a fat-soluble nutrient involved in brain health and function, has been associated with better cognitive performance in older adults. Our objective was to determine whether the dietary vitamin K intake was associated with the presence and severity of subjective memory complaint among older adults.
Observational, cross-sectional cohort study.
One hundred sixty older adults taking no vitamin K antagonist were included. The daily dietary vitamin K intake was assessed using a 50-item food frequency questionnaire. The subjective memory complaint was assessed at the same time using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). Serious subjective memory complaint was defined as MAC-Q score ≤15. Age, gender, body mass index, education level, number of comorbidities, history of stroke, objective cognitive disorders, functional autonomy, mood, serum concentrations of vitamin B12, TSH, albumin, and estimated glomerular filtration rate were used as potential confounders.
Compared to participants without serious subjective memory complaint, those with serious subjective memory complaint (n=110) had a lower mean dietary vitamin K intake (298.0±191.8μg/day versus 393.8±215.2μg/day, P=0.005). Increased log dietary vitamin K intake was positively associated with the MAC-Q score used as a quantitative variable (fully adjusted β=0.79, P=0.031), and inversely with serious subjective memory complaint (fully adjusted OR=0.34, P=0.017).
Increased dietary vitamin K intake was associated with fewer and less severe subjective memory complaint in older adults taking no vitamin K antagonists. These findings provide epidemiological data supporting future vitamin K replacement trials.
维生素K是一种参与大脑健康和功能的脂溶性营养素，增加其膳食摄入量与老年人更好的认知表现有关。我们的目的是确定膳食维生素K摄入量是否与老年人主观记忆抱怨的存在及严重程度相关。
观察性横断面队列研究。
纳入160名未服用维生素K拮抗剂的老年人。使用50项食物频率问卷评估每日膳食维生素K摄入量。同时使用记忆抱怨问卷（MAC-Q；评分0 - 30，分数越高越好）评估主观记忆抱怨。严重主观记忆抱怨定义为MAC-Q评分≤15。年龄、性别、体重指数、教育水平、合并症数量、中风病史、客观认知障碍、功能自主性、情绪、血清维生素B12浓度、促甲状腺激素、白蛋白以及估算肾小球滤过率被用作潜在混杂因素。
与无严重主观记忆抱怨的参与者相比，有严重主观记忆抱怨的参与者（n = 110）的膳食维生素K平均摄入量较低（298.0±191.8μg/天对393.8±215.2μg/天，P = 0.005）。膳食维生素K摄入量的对数值增加与作为定量变量的MAC-Q评分呈正相关（完全调整后β = 0.79，P = 0.031），与严重主观记忆抱怨呈负相关（完全调整后OR = 0.34，P = 0.017）。
在未服用维生素K拮抗剂的老年人中，膳食维生素K摄入量增加与主观记忆抱怨较少且程度较轻有关。这些发现提供了流行病学数据，支持未来的维生素K替代试验。
