Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
CNS Neurol Disord Drug Targets. 2018;17(4):267-271. doi: 10.2174/1871527317666180202110056.
BACKGROUND & OBJECTIVE: Increased level of reactive oxygen species is a hallmark of common neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease. ROS can oxidize macromolecules including DNA, lipids and proteins and cause oxidative damage to the cell. Emerging evidence indicate that potassium channels in the central nervous system are no exceptions to these oxidative modifications.
In this mini-review, we summarized recent reports on the oxidation of potassium channels in the CNS and the consequently resulted changes in cell functions and viability, with focus on its implications in neurodegenerative diseases.
活性氧（ROS）水平升高是阿尔茨海默病和帕金森病等常见神经退行性疾病的标志之一。ROS 可以氧化包括 DNA、脂质和蛋白质在内的大分子物质，导致细胞发生氧化损伤。新出现的证据表明，中枢神经系统中的钾通道也不例外，会发生这些氧化修饰。
在这篇综述中，我们总结了最近关于中枢神经系统中钾通道氧化及其导致的细胞功能和活力变化的报道，重点讨论了其在神经退行性疾病中的意义。
