Oxidation of Potassium Channels in Neurodegenerative Diseases: A Mini-Review.

BACKGROUND & OBJECTIVE: Increased level of reactive oxygen species is a hallmark of common neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease. ROS can oxidize macromolecules including DNA, lipids and proteins and cause oxidative damage to the cell. Emerging evidence indicate that potassium channels in the central nervous system are no exceptions to these oxidative modifications.

CONCLUSION

In this mini-review, we summarized recent reports on the oxidation of potassium channels in the CNS and the consequently resulted changes in cell functions and viability, with focus on its implications in neurodegenerative diseases.