Sports Science Research Center, Zhejiang College of Sports, Hangzhou, China.
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
Channels (Austin). 2019 Dec;13(1):477-482. doi: 10.1080/19336950.2019.1684428.
Lysosomes are central organelles that recycle materials and energy to maintain intracellular homeostasis. Lysosomes are capable of sensing environmental cues such as nutrition to regulate their function accordingly. Whether lysosomes can sense redox signaling, however, was unclear. Here in this review, we summarized recent evidence of lysosomal ion channel as redox sensors for this organelle. We also discussed their roles in lysosomal diseases that features imbalanced redox.
溶酶体是回收材料和能量以维持细胞内稳态的核心细胞器。溶酶体能够感知营养等环境线索，从而相应地调节其功能。然而，溶酶体是否能够感知氧化还原信号尚不清楚。在这篇综述中，我们总结了最近关于溶酶体离子通道作为该细胞器氧化还原传感器的证据。我们还讨论了它们在以氧化还原失衡为特征的溶酶体疾病中的作用。
