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岩藻聚糖硫酸酯通过促进线粒体生物发生和维持肠道微生物组稳态来改善 D-半乳糖诱导的认知功能障碍。

Fucoidan Improves D-Galactose-Induced Cognitive Dysfunction by Promoting Mitochondrial Biogenesis and Maintaining Gut Microbiome Homeostasis.

机构信息

School of Public Health, Qingdao University, Qingdao 266071, China.

Basic Medical College, Qingdao University, Qingdao 266071, China.

出版信息

Nutrients. 2024 May 17;16(10):1512. doi: 10.3390/nu16101512.

DOI:10.3390/nu16101512
PMID:38794753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11124141/
Abstract

Recent studies have indicated that fucoidan has the potential to improve cognitive impairment. The objective of this study was to demonstrate the protective effect and possible mechanisms of fucoidan in D-galactose (D-gal)-induced cognitive dysfunction. Sprague Dawley rats were injected with D-galactose (200 mg/kg, sc) and administrated with fucoidan (100 mg/kg or 200 mg/kg, ig) for 8 weeks. Our results suggested that fucoidan significantly ameliorated cognitive impairment in D-gal-exposed rats and reversed histopathological changes in the hippocampus. Fucoidan reduced D-gal-induced oxidative stress, declined the inflammation level and improved mitochondrial dysfunction in hippocampal. Fucoidan promoted mitochondrial biogenesis by regulating the PGC-1α/NRF1/TFAM pathway, thereby improving D-gal-induced mitochondrial dysfunction. The regulation effect of fucoidan on PGC-1α is linked to the upstream protein of APN/AMPK/SIRT1. Additionally, the neuroprotective action of fucoidan could be related to maintaining intestinal flora homeostasis with up-regulation of , and and down-regulation of . In summary, fucoidan may be a natural, promising candidate active ingredient for age-related cognitive impairment interventions.

摘要

最近的研究表明，褐藻糖胶具有改善认知障碍的潜力。本研究旨在证明褐藻糖胶在半乳糖（D-gal）诱导的认知功能障碍中的保护作用及可能的机制。Sprague Dawley 大鼠腹腔注射半乳糖（200 mg/kg），并灌胃给予褐藻糖胶（100 mg/kg 或 200 mg/kg）8 周。结果表明，褐藻糖胶显著改善了 D-gal 暴露大鼠的认知障碍，并逆转了海马的组织病理学变化。褐藻糖胶降低了 D-gal 诱导的氧化应激，降低了海马中的炎症水平，并改善了线粒体功能障碍。褐藻糖胶通过调节 PGC-1α/NRF1/TFAM 通路促进线粒体生物发生，从而改善 D-gal 诱导的线粒体功能障碍。褐藻糖胶对 PGC-1α 的调节作用与 APN/AMPK/SIRT1 的上游蛋白有关。此外，褐藻糖胶的神经保护作用可能与维持肠道菌群平衡有关，上调 和 ，下调 。总之，褐藻糖胶可能是一种天然的、有前途的干预与年龄相关的认知障碍的活性成分。

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