Tulipan N, Huang S, Whetsell W O, Allen G S
Brain Res. 1986 Jul 2;377(1):163-7. doi: 10.1016/0006-8993(86)91202-3.
It is reported that unilateral grafts of neonatal striatal tissue protect the recipient from the lethal aphagia and adipsia produced by bilateral intrastriatal injection of 10 nmol of kainic acid in rats. It is shown that neither adult striatum nor neonatal tissue from other sites have the same lifesaving effect and that the salutary effect of the graft is dependent upon graft survival. Grafts from a histoincompatible donor are apparently rejected, leading to the death of the recipient. Cyclosporine inhibits rejection thereby enabling recipient survival. It is postulated that the graft exerts a neurohumoral influence that protects the striatum from the toxic effect of kainate.
据报道，新生纹状体组织的单侧移植可保护受体免受大鼠双侧纹状体内注射10纳摩尔 kainic 酸所产生的致命性摄食和饮水障碍。研究表明，成年纹状体或其他部位的新生组织均无相同的救命效果，且移植的有益效果取决于移植组织的存活。来自组织不相容供体的移植组织显然会被排斥，导致受体死亡。环孢素可抑制排斥反应，从而使受体存活。据推测，移植组织发挥神经体液影响，保护纹状体免受 kainate 的毒性作用。
