Sanberg P R, Henault M A, Deckel A W
Pharmacol Biochem Behav. 1986 Jul;25(1):297-300. doi: 10.1016/0091-3057(86)90269-8.
Huntington's disease is characterized by gross degeneration of the intrinsic neurons of the striatum, restless hyperkinetic choreiform movements and dementia. Rats which received injections of kainic acid have provided an extremely viable model for this extrapyramidal movement disorder. The present preliminary report investigated the effects of multiple homotopic transplantations of normal fetal Day 17 striatal ridge tissue into the lesioned striatum of male kainic acid-treated rats. Nine weeks after transplantation, the spontaneous nocturnal hyperkinetic locomotor abnormalities as measured by horizontal activity and total distance travelled were attenuated in the striatal transplanted animals compared to sciatic nerve transplanted controls. Similarly, the exacerbated response to d-amphetamine exhibited by the animal model was attenuated in the striatal transplanted animals. The striatal transplants reconstructed much of the gross morphology of the lesioned striatum, although acetylcholinesterase was found to be reduced.
亨廷顿舞蹈症的特征是纹状体内在神经元严重退化、坐立不安的运动亢进性舞蹈样动作以及痴呆。接受 kainic 酸注射的大鼠为这种锥体外系运动障碍提供了一个非常可行的模型。本初步报告研究了将正常胎龄 17 天的纹状体嵴组织多次同位移植到经 kainic 酸处理的雄性大鼠受损纹状体中的效果。移植 9 周后，与坐骨神经移植对照组相比，纹状体移植动物中通过水平活动和总行进距离测量的自发性夜间运动亢进性运动异常有所减轻。同样，动物模型对 d - 苯丙胺的加剧反应在纹状体移植动物中也有所减轻。纹状体移植重建了受损纹状体的大部分大体形态，尽管发现乙酰胆碱酯酶减少。
