Balanzà Vicente, Martínez-Fernández Irene, Sato Shusei, Yanofsky Martin F, Kaufmann Kerstin, Angenent Gerco C, Bemer Marian, Ferrándiz Cristina
Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universidad Politécnica de Valencia, 46022, Valencia, Spain.
Division of Biological Sciences, University of California San Diego, La Jolla, CA, 92093, USA.
Nat Commun. 2018 Feb 8;9(1):565. doi: 10.1038/s41467-018-03067-5.
Monocarpic plants have a single reproductive cycle in their lives, where life span is determined by the coordinated arrest of all meristems, or global proliferative arrest (GPA). The molecular bases for GPA and the signaling mechanisms involved are poorly understood, other than systemic cues from developing seeds of unknown nature. Here we uncover a genetic pathway regulating GPA in Arabidopsis that responds to age-dependent factors and acts in parallel to seed-derived signals. We show that FRUITFULL (FUL), a MADS-box gene involved in flowering and fruit development, has a key role in promoting meristem arrest, as GPA is delayed and fruit production is increased in ful mutants. FUL directly and negatively regulates APETALA2 expression in the shoot apical meristem and maintains the temporal expression of WUSCHEL which is an essential factor for meristem maintenance.
一年生植物在其生命中有一个单一的繁殖周期，其寿命由所有分生组织的协同停滞或整体增殖停滞（GPA）决定。除了来自未知性质发育种子的系统性信号外，GPA的分子基础和所涉及的信号传导机制了解甚少。在这里，我们发现了拟南芥中一条调节GPA的遗传途径，该途径对年龄依赖性因素作出反应，并与种子衍生信号平行起作用。我们表明，FRUITFULL（FUL）是一个参与开花和果实发育的MADS-box基因，在促进分生组织停滞方面起关键作用，因为在ful突变体中GPA延迟且果实产量增加。FUL直接负调控茎尖分生组织中APETALA2的表达，并维持WUSCHEL的时间表达，而WUSCHEL是分生组织维持的一个关键因素。
