Department of Nuclear Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Dis Markers. 2017;2017:1592598. doi: 10.1155/2017/1592598. Epub 2017 Dec 20.
To examine the association between fracture risk assessment tool (FRAX) scores and coronary artery calcification (CAC) score in adults.
The medical records of 81 adults who underwent both coronary computed tomography and bone mineral density (BMD) studies in a package during their health exams were reviewed at a regional hospital in Southern Taiwan. Data collected included health history, anthropomorphic characteristics, clinical laboratory results, and BMD. Fracture risk was determined using FRAX. Univariate and multivariate linear regression analysis were used to assess the association between CAC score and 10-year probability of hip fracture (HF) and major osteoporotic fracture (MOF) determined by FRAX.
The mean age of the patients was 55.8 years, and 63.0% were male. Univariate linear regression analysis showed that increases in MOF and HF risks, as measured by FRAX, were significantly and positively associated with CAC score. Multiple linear regression analysis adjusting for potential confounders showed that CAC score remained significantly associated with four FRAX indicators, including right MOF ( = 0.45, < 0.001), left MOF ( = 0.31, = 0.021), right HF ( = 0.38, = 0.001), and left HF ( = 0.23, = 0.049).
Increased risks of MOF and HF as determined by FRAX were significantly and independently associated with CAC score.
探讨骨折风险评估工具（FRAX）评分与成年人冠状动脉钙化（CAC）评分之间的关系。
在台湾南部的一家地区医院，对 81 名在健康检查中同时接受冠状动脉计算机断层扫描和骨密度（BMD）检查的成年人的病历进行了回顾性研究。收集的数据包括健康史、人体测量特征、临床实验室结果和 BMD。使用 FRAX 确定骨折风险。采用单变量和多变量线性回归分析评估 CAC 评分与 FRAX 确定的 10 年髋部骨折（HF）和主要骨质疏松性骨折（MOF）的 10 年概率之间的关系。
患者的平均年龄为 55.8 岁，63.0%为男性。单变量线性回归分析显示，FRAX 测量的 MOF 和 HF 风险增加与 CAC 评分呈显著正相关。调整潜在混杂因素的多变量线性回归分析显示，CAC 评分与 FRAX 的四个指标均显著相关，包括右侧 MOF（ = 0.45，<0.001）、左侧 MOF（ = 0.31， = 0.021）、右侧 HF（ = 0.38，<0.001）和左侧 HF（ = 0.23， = 0.049）。
FRAX 确定的 MOF 和 HF 风险增加与 CAC 评分显著独立相关。
