Xiamen-Borstel Joint Laboratory of Autoimmunity, Medical College of Xiamen University, Xiamen, China.
Priority Area Asthma and Allergy, Research Center Borstel, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Borstel, Germany.
Front Immunol. 2018 Jan 25;9:66. doi: 10.3389/fimmu.2018.00066. eCollection 2018.
Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death worldwide, is characterized by irreversible airflow limitation based on obstructive bronchiolitis, emphysema, and chronic pulmonary inflammation. Inhaled toxic gases and particles, e.g., cigarette smoke, are major etiologic factors for COPD, while the pathogenesis of the disease is only partially understood. Over the past decade, an increasing body of evidence has been accumulated for a link between COPD and autoimmunity. Studies with clinical samples have demonstrated that autoantibodies are present in sera of COPD patients and some of these antibodies correlate with specific disease phenotypes. Furthermore, evidence from animal models of COPD has shown that autoimmunity against pulmonary antigens occur during disease development and is capable of mediating COPD-like symptoms. The idea that autoimmunity could contribute to the development of COPD provides a new angle to understand the pathogenesis of the disease. In this review article, we provide an advanced overview in this field and critically discuss the role of autoantibodies in the pathogenesis of COPD.
慢性阻塞性肺疾病（COPD）是全球第四大致死原因，其特征是基于阻塞性细支气管炎、肺气肿和慢性肺炎症的不可逆气流受限。吸入的有毒气体和颗粒，例如香烟烟雾，是 COPD 的主要病因因素，而该疾病的发病机制尚不完全清楚。在过去的十年中，越来越多的证据表明 COPD 与自身免疫之间存在关联。对临床样本的研究表明，COPD 患者的血清中存在自身抗体，其中一些抗体与特定的疾病表型相关。此外，来自 COPD 动物模型的证据表明，针对肺抗原的自身免疫在疾病发展过程中发生，并且能够介导 COPD 样症状。自身免疫可能有助于 COPD 发展的观点为理解该疾病的发病机制提供了一个新视角。在这篇综述文章中，我们对该领域进行了深入概述，并批判性地讨论了自身抗体在 COPD 发病机制中的作用。
