School of Life Sciences, The University of Nottingham, Nottingham, United Kingdom.
School of Life Sciences, The University of Nottingham, Nottingham, United Kingdom.
Immunol Lett. 2019 Oct;214:8-15. doi: 10.1016/j.imlet.2019.08.007. Epub 2019 Aug 28.
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of death worldwide in which the involvement of autoimmunity has been widely investigated and debated. The role of autoantibodies in COPD has been extensively researched in recent years. The aim of this systematic review is to assess the association between autoantibodies and COPD and analyse whether autoantibody levels correlate with disease severity and/or phenotype. PubMed, Embase, OpenGrey and the reference lists of articles were searched. The strongest evidence for an association between autoantibodies and COPD lies with anti-endothelial/epithelial cell autoantibodies (7 studies, all positive), rheumatoid factor autoantibodies (4 studies, all positive), anti-cytokeratin autoantibodies (3 studies, all positive), anti-nuclear autoantibodies (8 studies, 7 positive) and anti-collagen autoantibodies (10 studies, 6 positive). This review also identifies several other autoantibodies which had both positive and negative associations with COPD, however the evidence for these was not as strong and/or the number of studies is low, and further research is required. In particular, a clear case can be made for the potential importance of autoantibodies to carbonylated proteins. The relationship between autoantibody levels and disease severity requires further research with only 17/43 studies investigating this; however, 12 of the studies did show a positive association, making it a promising area for future research. There was also not enough evidence available on the relationship between autoantibody levels and disease phenotype to draw any conclusions, with only 2 studies investigating it (1 positive and 1 negative). This review has shown very promising evidence for the association of several autoantibodies in COPD and has identified those autoantibodies which require further research.
慢性阻塞性肺疾病（COPD）是全球范围内的主要死亡原因之一，其中自身免疫的参与已被广泛研究和争论。近年来，人们对 COPD 中的自身抗体进行了广泛的研究。本系统评价的目的是评估自身抗体与 COPD 之间的关联，并分析自身抗体水平是否与疾病严重程度和/或表型相关。检索了 PubMed、Embase、OpenGrey 和文章的参考文献列表。自身抗体与 COPD 之间存在关联的最强证据来自于抗内皮/上皮细胞自身抗体（7 项研究，均为阳性）、类风湿因子自身抗体（4 项研究，均为阳性）、抗细胞角蛋白自身抗体（3 项研究，均为阳性）、抗核自身抗体（8 项研究，7 项阳性）和抗胶原自身抗体（10 项研究，6 项阳性）。本综述还确定了其他一些与 COPD 既有正相关又有负相关的自身抗体，但这些证据并不那么强，而且研究数量较少，需要进一步研究。特别是，针对羰基化蛋白的自身抗体的潜在重要性，可以提出明确的案例。自身抗体水平与疾病严重程度之间的关系需要进一步研究，只有 17/43 项研究对此进行了调查；然而，其中 12 项研究确实显示出正相关，这是未来研究的一个有前途的领域。自身抗体水平与疾病表型之间的关系也没有足够的证据来得出任何结论，只有 2 项研究对此进行了调查（1 项阳性，1 项阴性）。本综述非常有前景地证明了几种自身抗体与 COPD 的关联，并确定了那些需要进一步研究的自身抗体。
