Haddrell Allen E, Lewis David, Church Tanya, Vehring Reinhard, Murnane Darragh, Reid Jonathan P
School of Chemistry, University of Bristol, Bristol, BS8 1TS, UK.
Chippenham Research Centre, Chiesi Limited, Chippenham, Wiltshire, SN14 0AB, UK.
Ther Deliv. 2017 Dec;8(12):1051-1061. doi: 10.4155/tde-2017-0093.
Aerosols are dynamic systems, responding to variations in the surrounding environmental conditions by changing in size, composition and phase. Although, widely used in inhalation therapies, details of the processes occurring on aerosol generation and during inhalation have received little attention. Instead, research has focused on improvements to the formulation of the drug prior to aerosolization and the resulting clinical efficacy of the treatment. Here, we highlight the processes that occur during aerosol generation and inhalation, affecting aerosol disposition when deposited and, potentially, impacting total and regional doses. In particular, we examine the response of aerosol particles to the humid environment of the respiratory tract, considering both the capacity of particles to grow by absorbing moisture and the timescale for condensation to occur. [Formula: see text].
气雾剂是动态系统，会通过改变大小、成分和相态来响应周围环境条件的变化。尽管气雾剂在吸入疗法中广泛应用，但关于气雾剂产生过程以及吸入过程中发生的具体细节却很少受到关注。相反，研究重点一直放在雾化前药物制剂的改进以及由此产生的治疗临床疗效上。在此，我们着重介绍气雾剂产生和吸入过程中发生的各种过程，这些过程会影响沉积时气雾剂的分布情况，并可能影响总剂量和局部剂量。特别是，我们研究了气雾剂颗粒对呼吸道潮湿环境的反应，既考虑了颗粒通过吸收水分而生长的能力，也考虑了发生凝结的时间尺度。[公式：见正文]
