Di Nicolantonio R, Stevens J, Weaver D, Morgan T O
Clin Exp Pharmacol Physiol. 1986 Apr;13(4):311-4. doi: 10.1111/j.1440-1681.1986.tb00354.x.
Atrial natriuretic peptide (8-33; ANP) caused a prolonged hypotensive response following intravenous injection in anaesthetized rats. This response was abolished by captopril treatment and restored by concomitant angiotensin II infusion. These results suggest that ANP exerts its hypotensive action in the anaesthetized rat by the antagonism of the vasoconstrictor action of endogenous angiotensin II.
心房利钠肽（8 - 33；ANP）在麻醉大鼠静脉注射后引起了长时间的降压反应。卡托普利治疗可消除这种反应，而同时输注血管紧张素II可使其恢复。这些结果表明，ANP在麻醉大鼠中通过拮抗内源性血管紧张素II的血管收缩作用发挥其降压作用。
