• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

定义痉挛:一种新方法,考虑到当前运动障碍术语和肉毒毒素治疗。

Defining spasticity: a new approach considering current movement disorders terminology and botulinum toxin therapy.

机构信息

Head of Movement Disorders Section, Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Chulalongkorn Centre for Excellence on Parkinson's Disease and Related Disorders, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

出版信息

J Neurol. 2018 Apr;265(4):856-862. doi: 10.1007/s00415-018-8759-1. Epub 2018 Feb 8.

DOI:10.1007/s00415-018-8759-1
PMID:
29423615
Abstract

Spasticity is a symptom occurring in many neurological conditions including stroke, multiple sclerosis, hypoxic brain damage, traumatic brain injury, tumours and heredodegenerative diseases. It affects large numbers of patients and may cause major disability. So far, spasticity has merely been described as part of the upper motor neurone syndrome or defined in a narrowed neurophysiological sense. This consensus organised by IAB-Interdisciplinary Working Group Movement Disorders wants to provide a brief and practical new definition of spasticity-for the first time-based on its various forms of muscle hyperactivity as described in the current movement disorders terminology. We propose the following new definition system: Spasticity describes involuntary muscle hyperactivity in the presence of central paresis. The involuntary muscle hyperactivity can consist of various forms of muscle hyperactivity: spasticity sensu strictu describes involuntary muscle hyperactivity triggered by rapid passive joint movements, rigidity involuntary muscle hyperactivity triggered by slow passive joint movements, dystonia spontaneous involuntary muscle hyperactivity and spasms complex involuntary movements usually triggered by sensory or acoustic stimuli. Spasticity can be described by a documentation system grouped along clinical picture (axis 1), aetiology (axis 2), localisation (axis 3) and additional central nervous system deficits (axis 4). Our new definition allows distinction of spasticity components accessible to BT therapy and those inaccessible. The documentation sheet presented provides essential information for planning of BT therapy.

摘要

痉挛是一种在许多神经系统疾病中出现的症状,包括中风、多发性硬化症、缺氧性脑损伤、创伤性脑损伤、肿瘤和遗传性退行性疾病。它影响了大量的患者,并可能导致严重的残疾。到目前为止,痉挛只是被描述为上运动神经元综合征的一部分,或者在狭义的神经生理学意义上被定义。由 IAB-跨学科工作组运动障碍组织的这项共识旨在提供一个简短而实用的痉挛新定义-这是第一次基于当前运动障碍术语中描述的各种肌肉过度活动形式。我们提出了以下新的定义系统:痉挛描述了在中枢性瘫痪存在的情况下的不随意肌肉过度活动。不随意肌肉过度活动可以包括各种形式的肌肉过度活动:痉挛严格意义上描述了由快速被动关节运动触发的不随意肌肉过度活动,僵硬描述了由缓慢被动关节运动触发的不随意肌肉过度活动,肌张力障碍描述了自发性不随意肌肉过度活动,痉挛是一种复杂的不随意运动,通常由感觉或听觉刺激触发。痉挛可以通过一个沿着临床表现(轴 1)、病因(轴 2)、定位(轴 3)和额外的中枢神经系统缺陷(轴 4)分组的文档系统来描述。我们的新定义允许区分可接受 BT 治疗的痉挛成分和不可接受的痉挛成分。所提出的文档表提供了 BT 治疗计划的重要信息。

相似文献

1
Defining spasticity: a new approach considering current movement disorders terminology and botulinum toxin therapy.定义痉挛:一种新方法,考虑到当前运动障碍术语和肉毒毒素治疗。
J Neurol. 2018 Apr;265(4):856-862. doi: 10.1007/s00415-018-8759-1. Epub 2018 Feb 8.
2
Botulinum toxin therapy for treatment of spasticity in multiple sclerosis: review and recommendations of the IAB-Interdisciplinary Working Group for Movement Disorders task force.肉毒杆菌毒素治疗多发性硬化症中的痉挛:IAB-运动障碍跨学科工作组特别工作组的综述与建议
J Neurol. 2017 Jan;264(1):112-120. doi: 10.1007/s00415-016-8304-z. Epub 2016 Oct 27.
3
[The efficacy of botulinum toxin therapy in patients with upper limb spasticity due to traumatic brain injury].[肉毒杆菌毒素疗法对创伤性脑损伤所致上肢痉挛患者的疗效]
Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(8):30-35. doi: 10.17116/jnevro20161168130-35.
4
Spasticity treatment with botulinum toxins.肉毒杆菌毒素治疗痉挛
J Neural Transm (Vienna). 2008;115(4):607-16. doi: 10.1007/s00702-007-0833-2. Epub 2008 Apr 4.
5
Intrathecal Baclofen therapy in Germany: Proceedings of the IAB-Interdisciplinary Working Group for Movement Disorders Consensus Meeting.德国鞘内注射巴氯芬疗法:IAB 运动障碍跨学科工作组共识会议纪要
J Neural Transm (Vienna). 2015 Nov;122(11):1573-9. doi: 10.1007/s00702-015-1425-1. Epub 2015 Jul 16.
6
Local treatment of dystonia and spasticity with injections of botulinum-A toxin.采用注射A型肉毒杆菌毒素对肌张力障碍和痉挛进行局部治疗。
Axone. 1993 Jun;14(4):85-8.
7
Common goal areas in the treatment of upper limb spasticity: a multicentre analysis.上肢痉挛治疗中的常见目标领域:一项多中心分析。
Clin Rehabil. 2016 Jun;30(6):617-22. doi: 10.1177/0269215515593391. Epub 2015 Jul 3.
8
Botulinum neurotoxin in muscle overactivity.肉毒杆菌神经毒素与肌肉过度活动
J Head Trauma Rehabil. 2005 Nov-Dec;20(6):563-7. doi: 10.1097/00001199-200511000-00007.
9
Consensus guidelines for botulinum toxin therapy: general algorithms and dosing tables for dystonia and spasticity.肉毒毒素治疗共识指南:肌张力障碍和痉挛的一般算法和剂量表。
J Neural Transm (Vienna). 2021 Mar;128(3):321-335. doi: 10.1007/s00702-021-02312-4. Epub 2021 Feb 26.
10
Botulinum toxin A for spasticity, muscle spasms, and rigidity.A型肉毒杆菌毒素用于治疗痉挛、肌肉痉挛和强直。
Neurology. 1995 Apr;45(4):712-7. doi: 10.1212/wnl.45.4.712.

引用本文的文献

1
What stroke survivors say about living with upper limb spasticity and how they manage it.中风幸存者如何看待上肢痉挛的生活状态以及他们是如何应对的。
Aust Occup Ther J. 2025 Oct;72(5):e70045. doi: 10.1111/1440-1630.70045.
2
Excitation-inhibition imbalance in the motor control network: a key factor in post-stroke spasticity.运动控制网络中的兴奋-抑制失衡:中风后痉挛的关键因素。
Front Hum Neurosci. 2025 Aug 13;19:1615483. doi: 10.3389/fnhum.2025.1615483. eCollection 2025.
3
Neuromusculoskeletal modeling of spasticity: A scoping review.

本文引用的文献

1
Effects of repeated abobotulinumtoxinA injections in upper limb spasticity.反复注射阿博特肉毒毒素 A 对上肢痉挛的影响。
Muscle Nerve. 2018 Feb;57(2):245-254. doi: 10.1002/mus.25721. Epub 2017 Aug 13.
2
Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex): A Review in Multiple Sclerosis-Related Spasticity.Δ9-四氢大麻酚/大麻二酚口腔喷雾剂(Sativex):用于多发性硬化相关痉挛的综述。
Drugs. 2017 Apr;77(5):563-574. doi: 10.1007/s40265-017-0720-6.
3
Safety and efficacy of incobotulinumtoxinA doses up to 800 U in limb spasticity: The TOWER study.
痉挛的神经肌肉骨骼建模:一项范围综述。
PLoS One. 2025 May 14;20(5):e0320153. doi: 10.1371/journal.pone.0320153. eCollection 2025.
4
Long-Term Management of Post-Stroke Spasticity with Botulinum Toxin: A Retrospective Study.脑卒后痉挛的肉毒毒素长期管理:一项回顾性研究。
Toxins (Basel). 2024 Sep 3;16(9):383. doi: 10.3390/toxins16090383.
5
Surgical reconstruction for spasticity and contracture: An underutilised rehabilitative strategy of adult stroke.用于痉挛和挛缩的外科重建:成人中风未得到充分利用的康复策略。
JRSM Open. 2024 Sep 15;15(8):20542704241278544. doi: 10.1177/20542704241278544. eCollection 2024 Aug.
6
Living With Spasticity During the COVID-19 Pandemic: A Qualitative Study of Patient, Carer and Physician Experiences.在 COVID-19 大流行期间应对痉挛:对患者、护理者和医生体验的定性研究。
Health Expect. 2024 Oct;27(5):e70032. doi: 10.1111/hex.70032.
7
Enhancing Botulinum Toxin Injection Precision: The Efficacy of a Single Cadaveric Ultrasound Training Intervention for Improved Anatomical Localization.提高肉毒毒素注射精度:单次尸体超声培训干预改善解剖定位的疗效。
Toxins (Basel). 2024 Jul 2;16(7):304. doi: 10.3390/toxins16070304.
8
Spinal movement disorders in NMOSD, MOGAD, and idiopathic transverse myelitis: a prospective observational study.视神经脊髓炎谱系疾病、MOG 抗体病和特发性横贯性脊髓炎的脊柱运动障碍:一项前瞻性观察研究。
J Neurol. 2024 Sep;271(9):5875-5885. doi: 10.1007/s00415-024-12527-6. Epub 2024 Jul 8.
9
Assessing muscle architecture with ultrasound: implications for spasticity.用超声评估肌肉结构:对痉挛的影响。
Eur J Transl Myol. 2024 May 30;34(2):12397. doi: 10.4081/ejtm.2024.12397.
10
Improvement in Quality-of-Life-Related Outcomes Following Treatment with IncobotulinumtoxinA in Adults with Limb Spasticity: A Pooled Analysis.经英孚托品毒素 A 治疗后成人肢体痉挛相关生活质量改善的汇总分析。
Toxins (Basel). 2023 Dec 29;16(1):19. doi: 10.3390/toxins16010019.
用于肢体痉挛的高达800单位的因卡波糖毒素A剂量的安全性和有效性:TOWER研究。
Neurology. 2017 Apr 4;88(14):1321-1328. doi: 10.1212/WNL.0000000000003789. Epub 2017 Mar 10.
4
Safety and efficacy of incobotulinumtoxinA as a potential treatment for poststroke spasticity.incobotulinumtoxinA作为中风后痉挛潜在治疗方法的安全性和有效性。
Neuropsychiatr Dis Treat. 2016 Jan 27;12:251-63. doi: 10.2147/NDT.S86978. eCollection 2016.
5
Intrathecal Baclofen therapy in Germany: Proceedings of the IAB-Interdisciplinary Working Group for Movement Disorders Consensus Meeting.德国鞘内注射巴氯芬疗法:IAB 运动障碍跨学科工作组共识会议纪要
J Neural Transm (Vienna). 2015 Nov;122(11):1573-9. doi: 10.1007/s00702-015-1425-1. Epub 2015 Jul 16.
6
Safety aspects of incobotulinumtoxinA high-dose therapy.注射用A型肉毒毒素高剂量疗法的安全性问题。
J Neural Transm (Vienna). 2015 Feb;122(2):327-33. doi: 10.1007/s00702-014-1252-9. Epub 2014 Jul 17.
7
OnabotulinumtoxinA muscle injection patterns in adult spasticity: a systematic literature review.成人性痉挛的肉毒毒素 A 肌内注射模式:系统文献回顾。
BMC Neurol. 2013 Sep 8;13:118. doi: 10.1186/1471-2377-13-118.
8
Incidence estimate and guideline-oriented treatment for post-stroke spasticity: an analysis based on German statutory health insurance data.基于德国法定健康保险数据的卒中后痉挛发生率估计和指南导向治疗分析。
Int J Gen Med. 2013;6:135-44. doi: 10.2147/IJGM.S36030. Epub 2013 Mar 13.
9
Clinical applications of botulinum toxin.肉毒杆菌毒素的临床应用
Curr Opin Microbiol. 2012 Jun;15(3):325-36. doi: 10.1016/j.mib.2012.05.012. Epub 2012 Jul 5.
10
Outcome of selective motor fasciculotomy in the treatment of upper limb spasticity.选择性运动束状切开术治疗上肢痉挛的疗效
J Pediatr Neurosci. 2011 Oct;6(Suppl 1):S118-25. doi: 10.4103/1817-1745.85730.