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提高肉毒毒素注射精度:单次尸体超声培训干预改善解剖定位的疗效。

Enhancing Botulinum Toxin Injection Precision: The Efficacy of a Single Cadaveric Ultrasound Training Intervention for Improved Anatomical Localization.

机构信息

Division of Physical Medicine and Rehabilitation, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Canadian Advances in Neuro-Orthopedics for Spasticity Congress (CANOSC), Kingston, ON K7K 1Z6, Canada.

出版信息

Toxins (Basel). 2024 Jul 2;16(7):304. doi: 10.3390/toxins16070304.

DOI:10.3390/toxins16070304
PMID:39057944
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11281316/
Abstract

Ultrasound guidance can enhance existing landmark-based injection methods, even through a brief and single exposure during a cadaveric training course. A total of twelve participants were enrolled in this training program, comprising nine physical medicine and rehabilitation specialists, one pediatrician, and two physician assistants. For each participant, one upper-limb muscle and one lower-limb muscle were randomly chosen from the preselected muscle group. Subsequently, participants were tasked with injecting both of their chosen cadaveric muscles with 1 mL of acrylic paint using a manual needle palpation technique, relying solely on their knowledge of anatomic landmarks. Participants then underwent a personalized, one-to-one ultrasound teaching session, lasting approximately five minutes, conducted by two highly experienced instructors. Following this instructive phase, participants were tasked with a second round of injections, targeting the same two muscles in the lower and upper limbs. However, this time, the injections were performed using anatomical landmarks and ultrasound guidance. To facilitate differentiation from the initial injections, a distinct color of acrylic paint was employed. When employing the anatomical landmark-based approach, the overall success rate for injections was 67%, with 16 out of 24 targeted muscles accurately injected. With the incorporation of ultrasound guidance, the success rate was 92%, precisely targeting 22 out of the 24 muscles under examination. There was an improvement in injection accuracy achievable through the integration of ultrasound guidance, even with minimal training exposure. Our single cadaveric ultra-sound training program contributes valuable insights to the utilization of ultrasound for anatomy training to help optimize the targeting of BoNT-A.

摘要

超声引导可以增强现有的基于体表标志的注射方法,即使在尸体培训课程中仅进行短暂的单次暴露也是如此。共有 12 名参与者参加了该培训计划,其中包括 9 名物理医学和康复专家、1 名儿科医生和 2 名医师助理。对于每个参与者,从预选的肌肉群中随机选择一块上肢肌肉和一块下肢肌肉。随后,参与者使用手动针触诊技术,仅依靠对解剖标志的了解,将 1 mL 丙烯颜料注入他们选择的两个尸体肌肉中。然后,参与者接受了由两位经验丰富的讲师进行的个性化一对一超声教学课程,大约持续五分钟。在这个教学阶段之后,参与者被要求进行第二轮注射,针对上肢和下肢的相同两块肌肉。然而,这次使用解剖标志和超声引导进行注射。为了便于与初始注射区分开来,使用了不同颜色的丙烯颜料。在使用基于解剖标志的方法时,注射的总体成功率为 67%,24 个目标肌肉中有 16 个被准确注射。使用超声引导时,成功率为 92%,在检查的 24 块肌肉中准确地定位了 22 块。即使仅接受了少量的培训,通过整合超声引导也可以提高注射的准确性。我们的单次尸体超声培训计划为超声在解剖学培训中的应用提供了有价值的见解,有助于优化 BoNT-A 的靶向性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b78/11281316/b95255b42daf/toxins-16-00304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b78/11281316/b95255b42daf/toxins-16-00304-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b78/11281316/b95255b42daf/toxins-16-00304-g001.jpg

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本文引用的文献

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Implementing ultrasound sessions to highlight living anatomy for large medical student cohorts.开展超声课程,为大批医学生凸显活体解剖结构。
Transl Res Anat. 2021 Jan;22:100088. doi: 10.1016/j.tria.2020.100088. Epub 2020 Sep 12.
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Best Practice Guidelines for the Management of Patients with Post-Stroke Spasticity: A Modified Scoping Review.《脑卒中后痉挛管理患者的最佳实践指南:改良范围综述》。
Toxins (Basel). 2024 Feb 10;16(2):98. doi: 10.3390/toxins16020098.
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Development of the McMaster Embalming Scale (MES) to assess embalming solutions for surgical skills training.
麦克马斯特防腐量表(MES)的开发,用于评估用于外科技能培训的防腐解决方案。
Clin Anat. 2023 Jul;36(5):754-763. doi: 10.1002/ca.24037. Epub 2023 Apr 3.
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AbobotulinumtoxinA Doses in Upper and Lower Limb Spasticity: A Systematic Literature Review.A型肉毒毒素在上肢和下肢痉挛中的剂量:系统文献回顾。
Toxins (Basel). 2022 Oct 26;14(11):734. doi: 10.3390/toxins14110734.
5
Perceived Benefits of a Cadaver-Based Ultrasound Procedure Workshop for Physical Medicine and Rehabilitation Trainees.尸体超声操作研习班对物理医学与康复专业住院医师的获益感知。
Am J Phys Med Rehabil. 2022 Feb 1;101(2):e18-e21. doi: 10.1097/PHM.0000000000001814.
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Ergonomic Recommendations in Ultrasound-Guided Botulinum Neurotoxin Chemodenervation for Spasticity: An International Expert Group Opinion.超声引导肉毒毒素化学神经切断术治疗痉挛的人体工效学建议:国际专家小组意见。
Toxins (Basel). 2021 Mar 31;13(4):249. doi: 10.3390/toxins13040249.
7
Reliability and Validity of the Modified Heckmatt Scale in Evaluating Muscle Changes With Ultrasound in Spasticity.改良赫克马特量表在评估痉挛状态下超声检测肌肉变化中的信效度
Arch Rehabil Res Clin Transl. 2020 Jul 1;2(4):100071. doi: 10.1016/j.arrct.2020.100071. eCollection 2020 Dec.
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A practical guide to optimizing the benefits of post-stroke spasticity interventions with botulinum toxin A: An international group consensus.实用指南:优化 A 型肉毒毒素治疗脑卒中后痉挛的获益:国际专家组共识。
J Rehabil Med. 2021 Jan 1;53(1):jrm00134. doi: 10.2340/16501977-2753.
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Accuracy of Ultrasound-Guided and Non-guided Botulinum Toxin Injection Into Neck Muscles Involved in Cervical Dystonia: A Cadaveric Study.超声引导与非引导下肉毒杆菌毒素注射到颈部肌张力障碍相关肌肉的准确性:一项尸体研究
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The Effects of Botulinum Toxin Injections on Spasticity and Motor Performance in Chronic Stroke with Spastic Hemiplegia.肉毒毒素注射对慢性脑卒中痉挛性偏瘫患者的痉挛和运动功能的影响。
Toxins (Basel). 2020 Jul 31;12(8):492. doi: 10.3390/toxins12080492.