Wang Xin, Zhao Qin, Deng Zhao-da, Wang Xiao-Yuan, Zhang Si-Gong, Shen Hai-Li
Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu, China.
Department of Rheumatology, Lanzhou University Second Hospital, Lanzhou 730030, Gansu, China;
Zhongguo Gu Shang. 2017 Jun 25;30(6):576-580. doi: 10.3969/j.issn.1003-0034.2017.06.019.
During choosing non-steroidal anti-inflammatory drugs(NSAIDs), risk factors should be evaluated in elder patients with rheumatoid arthritis. The present study focused on biological therapies, and elderly patients should be more concerned about the risk of infection when used it. Traditional Chinese medicine has advantages of obvious curative effect, especially for tripterygium wilfordii, large clinical trial on western and Chinese medical accurate drug strategies for old patients with rheumatoid arthritis. Old patients are easier to suffer from cardiac diseases and interstitial lung disease, rheumatoid arthritis could be controlled along with the treatment for coexistent disease. The incidence of rheumatoid arthritis in old patients is the same with other RA, and need to treat to target based on the aim of relieve pain and reduce activity of diseases, while the clinical charteristic and treatment target in elder patients with rheumatoid arthritis were not similar with other aged patient, so treatment standard target would vary with aging. Resent clinical studies excluded old patients, lead to lack of evidence-based medicine data. Clinical study for elder patients with rheumatoid arthritis are energetically carrying out, and could provide base and guide for clinical treatment.
在选择非甾体抗炎药（NSAIDs）时，应评估老年类风湿关节炎患者的危险因素。本研究聚焦于生物疗法，老年患者使用时应更关注感染风险。中药具有疗效显著的优势，尤其是雷公藤，针对老年类风湿关节炎患者中西医精准用药策略的大型临床试验。老年患者更容易患心脏病和间质性肺病，类风湿关节炎可与并存疾病一并治疗。老年患者类风湿关节炎的发病率与其他类风湿关节炎相同，需要根据缓解疼痛和降低疾病活动度的目标进行达标治疗，而老年类风湿关节炎患者的临床特征和治疗目标与其他老年患者不同，因此治疗标准目标会因年龄而异。近期的临床研究排除了老年患者，导致缺乏循证医学数据。针对老年类风湿关节炎患者的临床研究正在大力开展，可为临床治疗提供依据和指导。
