Talware Nandkishor S, Dias Remeth J, Gupta Vankadari Ramamohan
Jawaharlal Nehru Technical University, (JNTU) Hyderabad, Telangana, 500 085, India.
Department of Pharmaceutics, STES's Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (Bk.), Lonavala, Dist-Pune, Maharashtra, 410 401, India.
Curr Drug Deliv. 2018;15(6):755-764. doi: 10.2174/1567201815666180209114103.
The imbalance of hydrophilicity and lipophilicity along with a large molecular size (due to a unique chemical structure) of natural compounds or plant actives poses a significant challenge for their absorption through a biological membrane and thus, alters the therapeutic efficacy. Therefore, it is desirable to have a novel approach for such formulation in order to improve the solubility and bioavailability of these phytoconstituents as a phospholipid complexation. Herbal drugs are precisely, embedded and bound by phospholipids to form vesicular structures which are amphoteric in nature. Thus, the phytolipid complex technology is unique, in the respect that it has a higher stability profile owing to its amphoteric nature or owing to its solubility in aqueous as well as oil media. It also exhibits a greater absorption and bioavailability, as the drug molecules are embedded in the pockets of the phytosomal assembly, therefore, with more drug loading capability, protection from the gastric environment, and subsequently inactivation in gastro-intestinal tract (GIT). Phytolipid complexes have a great potential in the field of medicine, pharmaceuticals and cosmetics due to improved pharmacokinetics and pharmacological attributes. The present review explores the various aspects of phytolipid complexes concerning the phospholipids, vesicles, choice of ingredients, phytolipid complexation, advantages, preparation methods and their applications.
天然化合物或植物活性成分亲水性与亲脂性的失衡，以及因其独特化学结构导致的大分子尺寸，对其透过生物膜的吸收构成了重大挑战，进而改变了治疗效果。因此，需要一种新颖的制剂方法，通过磷脂络合来提高这些植物成分的溶解度和生物利用度。确切地说，草药药物被磷脂包裹并结合，形成具有两性性质的囊泡结构。因此，植物脂质复合物技术具有独特性，因为其两性性质或在水相和油相介质中的溶解性使其具有更高的稳定性。它还表现出更高的吸收和生物利用度，因为药物分子嵌入到植物脂质体组装体的口袋中，因此具有更大的载药能力、免受胃环境影响以及随后在胃肠道（GIT）中不被灭活。由于改善的药代动力学和药理学特性，植物脂质复合物在医学、制药和化妆品领域具有巨大潜力。本综述探讨了植物脂质复合物在磷脂、囊泡、成分选择、植物脂质络合、优势、制备方法及其应用等方面的各种情况。
