Gnananath Kattamanchi, Sri Nataraj Kalakonda, Ganga Rao Battu
Department of Pharmaceutical Analysis, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram-534202, Andhra Pradesh, India.
Department of Pharmacognosy, University College of Pharmaceutical Sciences, Vishakhapatnam-530003, Andhra Pradesh, India.
Adv Pharm Bull. 2017 Apr;7(1):35-42. doi: 10.15171/apb.2017.005. Epub 2017 Apr 13.
Phytoconstituents have been utilized as medicines for thousands of years, yet their application is limited owing to major hurdles like deficit lipid solubility, large molecular size and degradation in the gastric environment of gut. Recently, phospholipid-complex technique has unveiled in addressing these stumbling blocks either by enhancing the solubilizing capacity or its potentiating ability to pass through the biological membranes and it also protects the active herbal components from degradation. Hence, this phospholipid-complex-technique can enable researchers to deliver the phytoconstituents into systemic circulation by using certain conventional dosage forms like tablets and capsules. This review highlights the unique property of phospholipids in drug delivery, their role as adjuvant in health benefits, and their application in the herbal medicine systems to improve the bioavailability of active herbal components. Also we summarize the prerequisites for phytosomes preparation like the selection of type of phytoconstituents, solvents used, various methods employed in phytosomal preparation and its characterization. Further we discuss the key findings of recent research work conducted on phospholipid-based delivery systems which can enable new directions and advancements to the development of herbal dosage forms.
植物成分作为药物已被使用了数千年，但由于存在诸如脂溶性差、分子量大以及在胃肠道环境中易降解等主要障碍，其应用受到限制。最近，磷脂复合技术在解决这些障碍方面崭露头角，它要么通过增强增溶能力，要么通过增强其穿过生物膜的能力，并且还能保护活性草药成分不被降解。因此，这种磷脂复合技术能够使研究人员通过使用某些传统剂型（如片剂和胶囊）将植物成分输送到体循环中。本综述重点介绍了磷脂在药物递送中的独特性质、它们作为健康益处佐剂的作用以及它们在草药系统中的应用，以提高活性草药成分的生物利用度。我们还总结了制备植物脂质体的先决条件，如植物成分类型的选择、所用溶剂、植物脂质体制备中采用的各种方法及其表征。此外，我们讨论了近期基于磷脂的递送系统研究工作的关键发现，这些发现可为草药剂型的开发指明新方向并推动其进步。
