State Key Laboratory for Oxo Synthesis and Selective Oxidation, Center for Excellence in Molecular Synthesis, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences, Lanzhou, 730000, P. R. China.
University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Chem Asian J. 2018 Sep 4;13(17):2458-2464. doi: 10.1002/asia.201800068. Epub 2018 Mar 30.
A tetradentate nitrogen ligand containing a benzimidazole ring and an electron-rich pyridine ring was developed, the resulting manganese complex exhibited good activity in the C-H oxidation of simple alkanes. In particular, cyclic aliphatic alkanes were transformed into ketones in very good yields (up to 89 %) by using environmentally benign H O as the terminal oxidant. This protocol was also applied successfully in benzylic C-H oxidation, giving the corresponding ketones with very good selectivities. In addition, tertiary C-H bond oxidation of complex molecules by the manganese complex showed potential utility for assembling alcohols with good selectivity in late-stage chemical synthesis.
开发了一种含有苯并咪唑环和富电子吡啶环的四齿氮配体，所得锰配合物在简单烷烃的 C-H 氧化中表现出良好的活性。特别是，使用环境友好的 H 2 O 2 作为末端氧化剂，环状脂肪族烷烃可以非常高的收率（高达 89%）转化为酮。该方案也成功地应用于苄基 C-H 氧化，得到相应的酮，具有非常好的选择性。此外，锰配合物对复杂分子的叔 C-H 键氧化具有潜在的应用价值，可用于在晚期化学合成中以良好的选择性组装醇。
