Department of Retinal Signal Processing, The Netherlands Institute for Neuroscience, KNAW, Amsterdam, The Netherlands.
Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands.
Eye (Lond). 2018 May;32(5):904-914. doi: 10.1038/eye.2017.298. Epub 2018 Feb 9.
The first descriptions of ageing macula disorder (AMD), be it under other names, appeared in 1855 and 1868. The earliest accounts of AMD linked the presence of drusen with visual loss. It took a century before these connections between drusen and AMD were generally accepted by medical science and in clinical articles. The first signs of AMD appear in the region of the choriocapillaris, Bruch's membrane and the retinal pigment epithelium. The pathogenesis of drusen and of AMD is still uncertain. This is reflected in the wide variation in nomenclature of both, since the first publications.
最早对年龄相关性黄斑变性（AMD）的描述（以其他名称出现）出现于 1855 年和 1868 年。最早的 AMD 报道将 drusen 的存在与视力丧失联系起来。直到一个世纪后，医学科学和临床文章才普遍接受了 drusen 与 AMD 之间的这些联系。AMD 的最初迹象出现在脉络膜毛细血管、Bruch 膜和视网膜色素上皮区域。drusen 和 AMD 的发病机制仍不确定。这反映在两者的命名法上存在广泛差异，自首次出版以来一直如此。
