Department of Oncology, Jining No. 1 People's Hospital, Jining, Shandong, China.
Eur Rev Med Pharmacol Sci. 2018 Jan;22(2):417-421. doi: 10.26355/eurrev_201801_14190.
The aim of this study was to explore FOXM1-related LncRNA 1(FRLnc1) expression level in gastric cancer (GC) and demonstrate its association with the prognosis.
A total of 173 GC patients from Affiliated Hospital of Jining Medical University were enrolled in the study. GC tissue samples were quantified for FRLnc1 expression level using quantitative PCR (qPCR) method. The relevance between FRLnc1 expression and clinicopathological features was determined by x2-test. The association between FRLnc1 expression and overall survival was estimated by the Kaplan-Meier method. Multivariate and univariate analysis were performed to explore whether FRLnc1 was an independent prognostic factor for GC patients.
We found that FRLnc1 expression was higher in GC tissues than corresponding adjacent tissues (p < 0.01). Increased FRLnc1 expression was associated with depth of tumor (p = 0.004), differentiation degree (p = 0.032), distant metastasis (p = 0.007), TNM stage (p = 0.006) and lymph node metastasis (p = 0.012). More importantly, Kaplan-Meier survival analysis demonstrated that overall patient survival for those with low FRLnc1 expression was significantly longer than those patients with high FRLnc1 expression (p < 0.001). Multivariate analysis suggested that FRLnc1 expression was an independent prognostic marker for survival in patients with GC.
The data presented in this work firstly suggested that FRLnc1 may be a prognostic predictor in GC.
本研究旨在探讨胃癌（GC）中 FOXM1 相关长链非编码 RNA 1（FRLnc1）的表达水平，并证明其与预后的关系。
本研究共纳入了来自济宁医学院附属医院的 173 例 GC 患者。采用实时定量 PCR（qPCR）方法检测 GC 组织样本中 FRLnc1 的表达水平。通过 x2 检验确定 FRLnc1 表达与临床病理特征的相关性。采用 Kaplan-Meier 法评估 FRLnc1 表达与总生存期的关系。采用多变量和单变量分析探讨 FRLnc1 是否为 GC 患者的独立预后因素。
我们发现 FRLnc1 在 GC 组织中的表达高于相应的癌旁组织（p<0.01）。FRLnc1 表达升高与肿瘤浸润深度（p=0.004）、分化程度（p=0.032）、远处转移（p=0.007）、TNM 分期（p=0.006）和淋巴结转移（p=0.012）有关。更重要的是，Kaplan-Meier 生存分析表明，FRLnc1 低表达患者的总生存期明显长于 FRLnc1 高表达患者（p<0.001）。多变量分析表明，FRLnc1 表达是 GC 患者生存的独立预后标志物。
本研究首次表明，FRLnc1 可能是 GC 的一个预后预测指标。
