重症肌无力中的胸腺成像：在临床实践中的相关性。
Thymus imaging in myasthenia gravis: The relevance in clinical practice.
作者信息
Klimiec Elzbieta, Quirke Mary, Leite Maria Isabel, Hilton-Jones David
机构信息
Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford University Hospitals, Headley Way Headington, Oxford, OX3 9DU, United Kingdom.
出版信息
Muscle Nerve. 2018 Feb 9. doi: 10.1002/mus.26096.
INTRODUCTION
The ability to distinguish between normal thymus, thymic hyperplasia, and thymoma should aid clinical management and decision making in patients with myasthenia gravis (MG). We sought to determine the accuracy of routine imaging in predicting thymic pathology.
METHODS
We retrospectively analyzed records of patients with MG from the Oxford Myasthenia Centre registry who had undergone thymectomy. Each patient received 1 radiological diagnosis and 1 histological diagnosis.
RESULTS
We included 106 patients. Radiological and histological diagnoses agreed in 73 (68.9%) patients. Sensitivity and specificity, respectively, were calculated for each radiological diagnosis as follows: thymoma 90% and 95.5%, hyperplasia 17.6% and 98.6%, and normal 96.9% and 60.8%.
DISCUSSION
Routine chest computed tomography and MRI can effectively identify thymoma. However, they are not reliable tools to differentiate between thymic hyperplasia and normal thymus in patients with MG. Muscle Nerve, 2018.
引言
能够区分正常胸腺、胸腺增生和胸腺瘤，有助于重症肌无力（MG）患者的临床管理和决策制定。我们试图确定常规成像在预测胸腺病理方面的准确性。
方法
我们回顾性分析了牛津重症肌无力中心登记处接受胸腺切除术的MG患者的记录。每位患者都有1个放射学诊断和1个组织学诊断。
结果
我们纳入了106例患者。放射学诊断和组织学诊断在73例（68.9%）患者中一致。对每种放射学诊断分别计算敏感性和特异性如下：胸腺瘤为90%和95.5%，增生为17.6%和98.6%，正常为96.9%和60.8%。
讨论
常规胸部计算机断层扫描和磁共振成像能够有效识别胸腺瘤。然而，对于MG患者，它们并不是区分胸腺增生和正常胸腺的可靠工具。《肌肉与神经》，2018年
Zotero 插件