环境和管理相关因素对中国和英国临床健康猪群中猪链球菌流行和多样性的影响。
Effects of Environmental and Management-Associated Factors on Prevalence and Diversity of Streptococcus suis in Clinically Healthy Pig Herds in China and the United Kingdom.
机构信息
State Key Laboratory of Agricultural Microbiology and Key Laboratory of Veterinary Diagnosis (Ministry of Agriculture), College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
出版信息
Appl Environ Microbiol. 2018 Apr 2;84(8). doi: 10.1128/AEM.02590-17. Print 2018 Apr 15.
, a global zoonosis of pigs, shows regional differences in the prevalence of human-associated disease for Asian and non-Asian countries. The isolation rates and diversities of on tonsils of healthy slaughter pigs in China and the United Kingdom were studied for effects of geography, temperature, pig age, and farm type. Isolates underwent analysis of molecular serotype and multilocus sequence type and virulence-associated genotyping. Although we found no significant difference in positive isolation rates between Chinese and UK farms, the prevalences of serotypes previously associated with human disease were significantly greater in the Chinese collection ( = 0.003). A significant effect of temperature was found on the positive isolation rate of the Chinese samples and the prevalence of human disease-associated serotypes in the UK population (China, = 0.004; United Kingdom, = 0.024) and on the prevalence of isolates carrying key virulence genes in China ( = 0.044). Finally, we found marked diversity among isolates, with statistically significant temperature effects on detection of multiple strain types within individual pigs. This study highlighted the high carriage prevalence and diversity of among clinically healthy pig herds of China and the United Kingdom. The significant effect of temperature on prevalence of isolation, human disease-associated serotypes, and diversity carried by individual pigs may shed new light on geographic variations in human -associated disease. is a global zoonotic pathogen and also a normal colonizer mainly carried on the tonsil of pigs. Thus, it is important to study the effect of environmental and management-associated factors on the populations in clinically healthy pigs. In this research, we investigated the similarities and differences between the populations obtained from different pig ages, seasons, and farm management systems and discovered the relationship between high climatic temperature and the prevalence of .
猪源 ，一种全球性的人畜共患病病原体，在亚洲和非亚洲国家中，其与人类相关疾病的流行情况存在地域差异。本研究旨在探讨地理、温度、猪龄和养殖类型等因素对中国和英国健康屠宰猪扁桃体中 分离株的分离率和多样性的影响。对分离株进行了分子血清型和多位点序列型分析以及与毒力相关的基因分型。尽管我们未发现中、英养殖场的阳性分离率存在显著差异，但中国分离株中与人类疾病相关的血清型流行率显著高于英国（=0.003）。我们发现温度对中国样本的阳性分离率和英国人群中与人类疾病相关的血清型流行率（中国，=0.004；英国，=0.024）以及中国携带关键毒力基因的分离株的流行率有显著影响（=0.044）。最后，我们发现 分离株具有显著的多样性，个体猪中多个菌株类型的检测受到温度的显著影响。本研究强调了中国和英国临床健康猪群中 高携带率和多样性。温度对分离率、与人类疾病相关的血清型以及个体猪携带的多样性的显著影响可能为人类相关疾病的地理变异提供新的视角。 是一种全球性的人畜共患病病原体，也是一种主要定植于猪扁桃体的正常定植菌。因此，研究环境和管理相关因素对临床健康猪中 种群的影响非常重要。在本研究中，我们调查了不同猪龄、季节和养殖管理系统获得的 种群之间的异同，并发现了高气候温度与 的流行之间的关系。
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