卷曲乳杆菌可抑制与细菌性阴道病相关的阴道加德纳菌的阴道溶素表达，并降低细胞毒性。
Lactobacillus crispatus represses vaginolysin expression by BV associated Gardnerella vaginalis and reduces cell cytotoxicity.
作者信息
Castro Joana, Martins Ana Paula, Rodrigues Maria Elisa, Cerca Nuno
机构信息
Centre of Biological Engineering (CEB), Laboratory of Research in Biofilms Rosário Oliveira (LIBRO), University of Minho, Campus de Gualtar, Braga, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto, Porto, Portugal.
Centre of Biological Engineering (CEB), Laboratory of Research in Biofilms Rosário Oliveira (LIBRO), University of Minho, Campus de Gualtar, Braga, Portugal.
出版信息
Anaerobe. 2018 Apr;50:60-63. doi: 10.1016/j.anaerobe.2018.01.014. Epub 2018 Feb 7.
Using a chemically-defined medium simulating genital tract secretions, we have shown that pre-adhering Lactobacillus crispatus to Hela epithelial cells reduced cytotoxicity caused by Gardnerella vaginalis. This effect was associated to the expression of vaginolysin and was specific to L. crispatus interference, as other vaginal facultative anaerobes had no protective effect.
使用模拟生殖道分泌物的化学成分明确的培养基，我们已经表明，预先黏附于Hela上皮细胞的卷曲乳杆菌可降低阴道加德纳菌引起的细胞毒性。这种效应与阴道溶素的表达有关，并且是卷曲乳杆菌干扰所特有的，因为其他阴道兼性厌氧菌没有保护作用。
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