从白腐菌（MTCC-787）中合成银纳米粒子及其对人类病原菌的抗菌活性。
Synthesis of silver nanoparticles from Phenerochaete chrysosporium (MTCC-787) and their antibacterial activity against human pathogenic bacteria.
机构信息
Department of Microbiology and Immunology, Institute of Biomedical Sciences, College of Health Sciences, Mekelle University, Ethiopia.
Department of Food Science and Biotechnology, SeJong University, Gwangjingu, Seoul, Republic of Korea.
出版信息
Microb Pathog. 2018 Apr;117:68-72. doi: 10.1016/j.micpath.2018.02.008. Epub 2018 Feb 7.
The present study elucidates an eco-friendly method for synthesizing silver nanoparticles using Phenerochaete chrysosporium (MTCC-787), its bactericidal and cytotoxic effect were studied. The formation of nanoparticles was evidenced by color change and UV-Vis spectroscopy. Atomic Force Microscope and Transmission electron microscope, showed spherical and oval shapes particles in the sizes ranging between 34 and 90 nm. The biosynthesised silver nanoparticles showed significant antibacterial activity against Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus and Staphylococcus epidermidis at a high dose. Further, the nanoparticles observed to be non-toxic at 12.5 μg/ml towards fibroblast cells.
本研究阐明了一种使用白腐菌（MTCC-787）合成银纳米粒子的环保方法，并研究了其杀菌和细胞毒性作用。纳米粒子的形成通过颜色变化和紫外可见光谱得到证实。原子力显微镜和透射电子显微镜显示，在 34 至 90nm 的范围内，粒子呈球形和椭圆形。生物合成的银纳米粒子在高剂量下对铜绿假单胞菌、肺炎克雷伯菌、金黄色葡萄球菌和表皮葡萄球菌表现出显著的抗菌活性。此外，在 12.5μg/ml 时，纳米粒子对成纤维细胞观察到非毒性。
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