Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia.
Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, Australia.
Semin Respir Crit Care Med. 2018 Feb;39(1):45-55. doi: 10.1055/s-0037-1617412. Epub 2018 Feb 10.
Asthma remains the most prevalent chronic respiratory disorder, affecting people of all ages. The relationship between respiratory virus infection and asthma has long been recognized, though remains incompletely understood. In this article, we will address key issues around this relationship. These will include the crucial role virus infection plays in early life, as a potential risk factor for the development of asthma and lung disease. We will assess the impact that virus infection has on those with established asthma as a trigger for acute disease and how this may influence asthma throughout life. Finally, we will explore the complex interaction that occurs between the airway and the immune responses that make those with asthma so susceptible to the effects of virus infection.
哮喘仍然是最常见的慢性呼吸道疾病，影响所有年龄段的人。呼吸道病毒感染与哮喘之间的关系早已被认识，但仍不完全清楚。在本文中，我们将讨论这一关系的关键问题。这些问题将包括病毒感染在生命早期所扮演的关键角色，作为哮喘和肺部疾病发展的潜在危险因素。我们将评估病毒感染对已患有哮喘的人作为急性疾病诱因的影响，以及这如何影响他们一生的哮喘。最后，我们将探讨气道与免疫反应之间发生的复杂相互作用，使哮喘患者如此容易受到病毒感染的影响。
