Tosic Natasa, Petrovic Isidora, Grujicic Natasa Kovacevic, Davidovic Slobodan, Virijevic Marijana, Vukovic Nada Suvajdzic, Pavlovic Sonja, Stevanovic Milena
Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia.
Laboratory for Human Molecular Genetics, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Serbia.
Leuk Res. 2018 Apr;67:32-38. doi: 10.1016/j.leukres.2018.02.001. Epub 2018 Feb 6.
Aberrant expression of different SOX (SRY-related high mobility group (HMG) box) genes has been observed in number of tumors but, little is known about their expression patterns in hematological malignancies, especially in acute myeloid leukemia (AML). In this study we investigated SOX2, SOX3, SOX11, SOX14 and SOX18 gene expression in 50 de novo adult AML patients and correlated our findings with known clinical and molecular prognostic markers of the disease. We have found that these genes are overexpressed in 10-22% of patients and preliminary findings suggest that high expression level of these genes may have prognostic significance in AML patients. This is the first study focused on examining the expression level of SOX2, SOX3, SOX11, SOX14 and SOX18 genes in AML patients. Although this is a relatively limited study, initial findings indicate the need for further investigation of these genes, their potential roles in leukemia pathogenesis as well as prognosis in AML patients.
在许多肿瘤中均观察到不同的SOX（SRY相关高迁移率族（HMG）盒）基因存在异常表达，但对于它们在血液系统恶性肿瘤中的表达模式，尤其是在急性髓系白血病（AML）中的表达模式，人们了解甚少。在本研究中，我们调查了50例初发成年AML患者中SOX2、SOX3、SOX11、SOX14和SOX18基因的表达情况，并将我们的研究结果与该疾病已知的临床和分子预后标志物进行关联分析。我们发现这些基因在10%-22%的患者中过表达，初步研究结果表明这些基因的高表达水平可能对AML患者具有预后意义。这是第一项专注于检测AML患者中SOX2、SOX3、SOX11、SOX14和SOX18基因表达水平的研究。尽管这是一项相对有限的研究，但初步研究结果表明有必要进一步研究这些基因、它们在白血病发病机制中的潜在作用以及AML患者的预后情况。
