成人急性白血病中白血病原始细胞OCT3/4和SOX2抗原表达的意义
Significance of OCT3/4 and SOX2 antigens expression by leukemic blast cells in adult acute leukemia.
作者信息
Aref Salah, Khaled Omnyia, Menshawy Nadia El, Azmy Emad, Aref Mohamed, Salama Osama, Khaled Nada
机构信息
Hematology Unit, Mansoura University Oncology Center, Mansoura University, Mansoura, Egypt.
Hematology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
出版信息
J Egypt Natl Canc Inst. 2024 Feb 12;36(1):5. doi: 10.1186/s43046-024-00209-3.
OBJECTIVE
This study aimed to address the prognostic impact of SOX2 and OCT3/4 expression on adult acute leukemia patients' outcomes.
METHODS
SOX2 and OCT3/4 expression by blast cells were evaluated by flow cytometry in 80 acute leukemia patients and 8 healthy controls.
RESULTS
Baseline SOX2 and OCT3/4 expression were significantly higher in both ALL (P = < 0.001, P = 0.005 respectively) and AML patients (P < 0.001, P = 0.003 respectively) as compared to control, and decline at complete remission (CR) and elevated again at relapse. High SOX2 and OCT3/4 levels were significantly correlated with the presence of adverse risk stratification parameters.
CONCLUSION
Our findings indicated that both SOX2 and OCT3/4 could serve as biomarkers that could improve risk stratification of acute leukemia patients. Also, both SOX2 and OCT3/4 might be a therapeutic target, especially in resistant acute leukemia.
目的
本研究旨在探讨SOX2和OCT3/4表达对成人急性白血病患者预后的影响。
方法
采用流式细胞术评估80例急性白血病患者和8例健康对照者原始细胞中SOX2和OCT3/4的表达。
结果
与对照组相比，急性淋巴细胞白血病（ALL）患者（分别为P = <0.001，P = 0.005）和急性髓系白血病（AML）患者（分别为P < 0.001，P = 0.003）的基线SOX2和OCT3/4表达均显著升高，在完全缓解（CR）时下降，复发时再次升高。高SOX2和OCT3/4水平与不良风险分层参数的存在显著相关。
结论
我们的研究结果表明，SOX2和OCT3/4均可作为生物标志物，改善急性白血病患者的风险分层。此外，SOX2和OCT3/4都可能是治疗靶点，尤其是在难治性急性白血病中。
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